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Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.
抗原呈递途径的下调在上皮性卵巢癌晚期的转移和进展中发挥重要作用。
批准号:
21390449
负责人:
TANAKA Kenichi
金额:
$11.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies using EMT molecules for high-risk patients. This risk classification based on the gene expression signature is an accurate predictor of clinical outcome in patients with advanced stage high-grade serous ovarian cancer and has the potential to develop new therapeutic strategies for high-grade serous ovarian cancer patients.
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DOI: 10.1158/1078-0432.ccr-11-2725
发表时间: 2012-03-01
期刊: CLINICAL CANCER RESEARCH
影响因子: 11.5
作者: [Yoshihara, Kosuke, Tsunoda, Tatsuhiko, Tanaka, Kenichi]
通讯作者: Tanaka, Kenichi
High risk ovarian cancer based on 126-gene expression signeture is uniquely charcterized by down-regulation of antigen presentation passway Clin
基于 126 个基因表达特征的高风险卵巢癌的独特特征是抗原呈递通道下调 Clin
DOI: --
发表时间: 2012
期刊: Cancer Res
影响因子: 11.2
作者: [Yoshihara K, Tanaka K, 他27名]
通讯作者: 他27名
進行漿液性卵巣癌におけるZEB2高発現は独立した予後不良因子である
ZEB2在晚期浆液性卵巢癌中的高表达是一个独立的不良预后因素
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yoshihara, K., Tanaka, K, 他5名]
通讯作者: 他5名
Gene expression profile identified novel subclasses in advanced-stage serous ovarian cancers and revealed ZEB2 expression as the prognostic marker.
基因表达谱鉴定了晚期浆液性卵巢癌的新亚类,并揭示了 ZEB2 表达作为预后标志物。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yoshihara, K., Tanaka, K, 他13名]
通讯作者: 他13名
12
    Analysis of UBQLN2 based on loss of function model
    • 批准号:
      18K07504
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2018
    • 负责人:
      TANAKA Kenichi
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      2009
    • 负责人:
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    • 依托单位:
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    • 项目类别:
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    • 资助金额:
      $2.31万
    • 财政年份:
      2006
    • 负责人:
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    • 资助金额:
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      2026
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