Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

抗原呈递途径的下调在上皮性卵巢癌晚期的转移和进展中发挥重要作用。

• 批准号: 21390449
• 负责人: TANAKA Kenichi
• 金额: $ 11.56万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390449/
• 关键词: 卵巣がん; EMT; 抗原提供; 遺伝子発現プロファイル; 上皮性卵巣がん; 予後予測; 腫瘍内浸潤リンパ球; 上皮性卵巣癌; 分子標的治療薬; 上皮間葉移行

High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on a gene expression signature for predicting overall survival, leading to suggesting novel therapeutic strategies using EMT molecules for high-risk patients. This risk classification based on the gene expression signature is an accurate predictor of clinical outcome in patients with advanced stage high-grade serous ovarian cancer and has the potential to develop new therapeutic strategies for high-grade serous ovarian cancer patients.

高级别浆液性卵巢癌不仅在临床结果方面，而且在分子水平上都是异质性的。我们的目的是建立一个新的风险分类系统的基础上的基因表达的签名预测总生存期，从而提出新的治疗策略，使用EMT分子的高风险患者。这种基于基因表达特征的风险分类是晚期高级别浆液性卵巢癌患者临床结局的准确预测因子，并有可能为高级别浆液性卵巢癌患者开发新的治疗策略。

项目成果

High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway

• DOI: 10.1158/1078-0432.ccr-11-2725
• 发表时间: 2012-03-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Yoshihara, Kosuke;Tsunoda, Tatsuhiko;Tanaka, Kenichi
• 通讯作者: Tanaka, Kenichi

High risk ovarian cancer based on 126-gene expression signeture is uniquely charcterized by down-regulation of antigen presentation passway Clin

基于 126 个基因表达特征的高风险卵巢癌的独特特征是抗原呈递通道下调 Clin

• 发表时间: 2012
• 期刊: Cancer Res
• 影响因子: 11.2
• 作者: Yoshihara K;Tanaka K;他27名
• 通讯作者: 他27名

進行漿液性卵巣癌におけるZEB2高発現は独立した予後不良因子である

ZEB2在晚期浆液性卵巢癌中的高表达是一个独立的不良预后因素

• 发表时间: 2009
• 作者: Yoshihara;K.;Tanaka;K;他5名
• 通讯作者: 他5名

Gene expression profile identified novel subclasses in advanced-stage serous ovarian cancers and revealed ZEB2 expression as the prognostic marker.

基因表达谱鉴定了晚期浆液性卵巢癌的新亚类，并揭示了 ZEB2 表达作为预后标志物。

• 发表时间: 2009
• 作者: Yoshihara;K.;Tanaka;K;他13名
• 通讯作者: 他13名

Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicates ZEB2 in tumor progression and prognosis

• DOI: 10.1111/j.1349-7006.2009.01204.x
• 发表时间: 2009-08-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Yoshihara, Kosuke;Tajima, Atsushi;Tanaka, Kenichi
• 通讯作者: Tanaka, Kenichi