Investigation of uterine parameter to evaluate uterine receptivity

检查子宫参数以评估子宫容受性

• 批准号: 21390453
• 负责人: KIMURA Tadashi
• 金额: $ 11.48万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390453/
• 关键词: 生殖医学; 着床; 子宮; 不妊症; 妊娠高血圧症候群; preterm premature rapture of membrane (pPROM); intrauterine qrowth restriction (IUGR); reterm premature rapture of membrane (pPROM); intrauterine growth restiriction (IUGR); 血管透過性; インピーダンス; pH

Implantation is a key process for pregnancy. It is considered that abnormal implantation, which is occurred at the early stage of pregnancy, is a cause of not only infertility and also pregnancy related conditions and complications. We hypothesized that if we can assess implantation in real time, it could be useful for the treatment of infertility and pregnancy related conditions and complications. We investigated a new parameter to evaluate uterine receptivity using our mouse model.

着床是怀孕的关键过程。人们认为，怀孕早期发生的异常着床不仅是不孕症的原因，也是妊娠相关疾病和并发症的原因。我们假设，如果我们能够实时评估植入，它可能有助于治疗不孕症和妊娠相关疾病和并发症。我们使用小鼠模型研究了一个新参数来评估子宫容受性。

项目成果

Pravastain induces placental growth factor(PGF) and ameliorates preecl ampsia in a mouse model

普伐他汀在小鼠模型中诱导胎盘生长因子 (PGF) 并改善先兆子痫

• 发表时间: 2011
• 期刊: Proc Natl Acad Sci USA
• 作者: Kumasawa;K.;Ikawa;M.;Kidoya;H.;Kasuwa;H.;Saito;F.;Morioka;Y.;Takakura;N.;Kimura;T.;Okabe;M
• 通讯作者: M

Cesarean scar pregnancies succseefully treated with methotrexate

甲氨蝶呤成功治疗剖腹产疤痕妊娠

• 发表时间: 2009
• 期刊: Acta Obstetricia et Gynecologica Scandinavica
• 影响因子: 4.3
• 作者: Muraji;M.;Mabuchi;S.;Hisamoto;K.;Muranishi;M.;Kanagawa;T.;Nishio;Y.;Kimura;T.
• 通讯作者: T.

Macrophages regulate expression of alpha 1,2-fucosyltransferase genes in humanendometrial epithelial cells

巨噬细胞调节人子宫内膜上皮细胞中α1,2-岩藻糖基转移酶基因的表达

• 发表时间: 2012
• 期刊: Mol Hum Reprod
• 影响因子: 4
• 作者: Nakamura;H.;Jasper;M. J.;Hull;M. L.;Aplin;J. D.;Robertson;S. A
• 通讯作者: S. A

Calcineurin/NFAT pathway: a novel regulator of parturition.

钙调神经磷酸酶/NFAT 通路：一种新型的分娩调节因子。

• 发表时间: 2009
• 期刊: Am J Reprod Immunol 62(1)
• 作者: Tabata;C.;Ogita;K.;Sato;K.;Nakamura;H.;Qing;Z.;Negoro;H.;Kumasawa;K.;Temma-Asano;K.;Tsutsui;T.;Nishimori;K.;Kimura;T.
• 通讯作者: T.

Reliable predictors of neonatal immune thrombocytopenia in pregnant women with idiopathic thrombocytopenic purpura

• DOI: 10.1002/ajh.22178
• 发表时间: 2012-01-01
• 期刊: AMERICAN JOURNAL OF HEMATOLOGY
• 影响因子: 12.8
• 作者: Koyama, Shinsuke;Tomimatsu, Takuji;Kimura, Tadashi
• 通讯作者: Kimura, Tadashi