New woun d management strategy by distraction of wound biofilm

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Quorum-sensing(QS)systems regulate virulence factors in Pseudomonas aeruginosa, which produces autoinducers. Accerelations of wound healing were not observed when inoculated with ΔlasI or ΔrhlI in place of PAO1 and cancelled when co-treated with these anti HSL antisera, respectively, but not with control rabbit serum. By contrast, administration of HSL significantly accelerated the re-epithelialization. These results suggest that HSL may be deeply involved in the skin wound healing during P. aeruginosa infection.Low-energy extracorporeal shockwave treatment(LE-ESWT)has been demonstrated to accelerate wound repair. E-NOS is induced at the wound tissues by LE-ESWT and plays a critical role in the therapeutic effects of this treatment accelerating the wound healin g through promoting VEGF expression and neo-vascularization.