Development of the cure by the transgenics using the nano bubble to the Recklinghausen disease

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Initially the aim of this study was development of a gene therapy of von Recklinghausen's disease. However, because it became clear that integration of NF-1 gene into the vector was difficult, we have changed the target to Malignant peripheral nerve sheath tumor (MPNST), complicating disease of von Recklinghausen's disease.We have observed a marked decrease in number of cells by transfection of IFN-α and IFN-γ gene into cells delived from MPNST.