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Craniofacial regeneration in consideration of mesenchymal stem cells and embryology

考虑间充质干细胞和胚胎学的颅面再生

基本信息

批准号：
21390479
负责人：
HIRANO Akiyoshi
金额：
$ 11.15万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Recent genome-wide association studies identified susceptibility loci for nonsyndromic cleft lip with or without cleft palate(NSCL±P) on 8q24. 21, 10q25. 3, 13q31. 1, 15q13. 3, 17q22 and 18q22 in Europe-origin populations. Our study was to determine whether 8q24. 21 was a susceptibility locus for the development of NSCL±P in Japanese patients using DNA samples. Our results suggest that the 8q24. 21 locus is not associated with susceptibility to NSCL±P in Japanese patients and provide further evidence that ethnicity is a strong factor in determining susceptibility loci, albeit using a limited number of samples. Further study is needed to identify regions involved in the development of NSCL±P in the Japanese population.Next, a high dose of ionizing external radiation damage to the skin and soft tissue and craniofacial embryonic development results in changes in function as well as in the general body condition. Basic fibroblast growth factor(bFGF) is primarily considered as a potent angiogenic growth factor. Resurfacing with a dermal component is required, and bFGF stimulates wound healing and enhances human skin-derived mesenchymal stem cells under serum-free conditions in a dose-dependent manner. The bFGF improved and maintained the tissue viability after immediate irradiation in the skin and soft tissue trough tissue stem cells in situ.

最近的全基因组关联研究确定了8q24上非综合征性唇裂合并或不合并腭裂(NSCL±P)的易感基因。21，10q25。3、13q31。1，15q13。3、17q22和18q22在欧洲起源群体中。我们的研究是为了确定8q24是否存在。从DNA样本看，21是日本人NSCL±P的易感基因。我们的结果表明，8q24。21位点与日本患者NSCL±P的易感性无关，并提供了进一步的证据，即种族是决定易感基因座的一个强有力的因素，尽管使用的样本数量有限。在日本人群中，NSCL±P的发生还需要进一步的研究。其次，高剂量的电离外部辐射对皮肤和软组织以及头面部胚胎发育的损害会导致功能和一般身体状况的变化。碱性成纤维细胞生长因子(碱性成纤维细胞生长因子)被认为是一种强有力的血管生成因子。在无血清条件下，碱性成纤维细胞生长因子以剂量依赖的方式促进伤口愈合和增强人皮肤来源的间充质干细胞。碱性成纤维细胞生长因子可提高和维持皮肤和软组织中即刻照射后的组织活力。