Myeloid-associated immunoglobulin-like receptors, CD300 are promising antibody-therapeutic targets for sepsis

骨髓相关免疫球蛋白样受体 CD300 是脓毒症有前途的抗体治疗靶点

• 批准号: 21390481
• 负责人: TAHARA Satoko
• 金额: $ 11.32万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390481/
• 关键词: 救急蘇生学; 敗血症; 抗体療法; CD300a; CD300d; エンドトキシンショック; MAIR-I; MAIR-II; TLR4; 盲腸結紮穿孔法; 敗血症モデル

An appropriate activation of innate immune responses is crucial for control microbe infection. An excessive activation and dysfunction of innate immune responses leads to onset of sepsis. To elucidate the regulatory mechanism of innate immune responses is critical for establish the therapeutic approaches for sepsis. We have recently identified myeloid-associated immunoglobulin-like receptors, such as MAIR-I (CD300a) and MAIR-II (CD300d), and found that these receptors are crucial for regulating innate immune responses. Furthermore, administration of a monoclonal antibody against MAIR-I prolonged the survival of mice after cecal ligation and puncture (CLP)-induced sepsis.

适当激活先天免疫反应对于控制微生物感染至关重要。先天免疫反应的过度激活和功能障碍会导致败血症的发生。阐明先天免疫反应的调节机制对于建立脓毒症的治疗方法至关重要。我们最近鉴定了骨髓相关免疫球蛋白样受体，例如 MAIR-I (CD300a) 和 MAIR-II (CD300d)，并发现这些受体对于调节先天免疫反应至关重要。此外，施用针对MAIR-I的单克隆抗体可延长盲肠结扎穿刺（CLP）诱导的败血症后小鼠的存活率。

项目成果

An immunoglobulin-like receptor, Allergin-1, inhibits IgE-mediated immediate hypersensitivity reactions

免疫球蛋白样受体 Allergin-1 可抑制 IgE 介导的速发型超敏反应

• 发表时间: 2012
• 作者: 永田公二;木下義晶;手柴理沙;江角元史郎;増本幸二;田口智章;田原聡子
• 通讯作者: 田原聡子

リポジトリ論文

储存库论文

Critical role of DNAX accessory molecule-1 (DNAM-1) in the development of acute graft-versus-host disease in mice

• DOI: 10.1073/pnas.1005582107
• 发表时间: 2010-10-26
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Nabekura, Tsukasa;Shibuya, Kazuko;Shibuya, Akira
• 通讯作者: Shibuya, Akira

リポジトリ論文URL

存储库文章 URL

An immunoglobulin-like receptor, Allergin-1, inhibits allergic diseases

免疫球蛋白样受体 Allergin-1 可抑制过敏性疾病

• 发表时间: 2012
• 作者: 矢野健太郎;関根秀一;根本華奈子;不破亨;堀江利治;田原聡子
• 通讯作者: 田原聡子