Myeloid-associated immunoglobulin-like receptors, CD300 are promising antibody-therapeutic targets for sepsis

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An appropriate activation of innate immune responses is crucial for control microbe infection. An excessive activation and dysfunction of innate immune responses leads to onset of sepsis. To elucidate the regulatory mechanism of innate immune responses is critical for establish the therapeutic approaches for sepsis. We have recently identified myeloid-associated immunoglobulin-like receptors, such as MAIR-I (CD300a) and MAIR-II (CD300d), and found that these receptors are crucial for regulating innate immune responses. Furthermore, administration of a monoclonal antibody against MAIR-I prolonged the survival of mice after cecal ligation and puncture (CLP)-induced sepsis.