What is required for periodontal ligament regeneration?

牙周膜是连接牙根与骨的纤维结缔组织，在固位牙中起着重要作用。在这项研究中，我们的目的是确定干细胞，信号元件，和支架适合于牙周组织的再生，严重受损的深龋，严重牙周炎，创伤。本文报道了PDL干细胞中表达与间充质干细胞相同标志物的细胞基本符合PDL干细胞的标准，作为信号传导元件的候选细胞，列举了TGF-β 1、bFGF、bFGF后TGF-β 1的连续处理、NGF、GDNF、EGF、机械应力、血管紧张素II、白细胞介素-11和钙离子;包括钙和树脂如Superbond的材料显示出作为PDL干细胞支架的功效。

As periodontal ligament(PDL) is a fibrous connective tissue connecting tooth root to bone, it plays an important role in retaining tooth. In this research, we aimed to identify stem cells, signaling elements, and scaffolds suitable for the regeneration of PDL tissue that is severely damaged by deep caries, serious periodontitis, and trauma. Here we report that for PDL stem cells, the cells expressing the same markers as mesenchymal stem cell basically meet the criteria of PDL stem cells ; as candidates suitable as signaling elements, TGF-beta1, bFGF, serial treatment of TGF-beta1 after bFGF, NGF, GDNF, EGF, mechanical stress, Angiotensin II, Interleukin-11, and calcium are enumerated ; materials including calcium and the resin such as Superbond showed efficacy as scaffolds for PDL stem cells.