Development on scaffold-free 3D regenerative cartilage as surgical implants

作为手术植入物的无支架 3D 再生软骨的开发

• 批准号: 21390532
• 负责人: HOSHI Kazuto
• 金额: $ 11.4万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390532/
• 关键词: 再生軟骨; インプラント; スカフォールド; 顎顔面; 軟骨細胞

We have produced complex regenerative cartilage or regenerative joints that consist of two layers of cartilage and bone to apply them to the repair of cleft lip-nose or temporomandibular joint reconstruction. Regarding every regenerative cartilage which we have invented, a large amount of cell pellets were produced, and then physical strength and resistance to hypoxia or undernutrition were added to them. After that, 3D shape was formed by accumulating and fusing those pellets together. At transplantation, tissue tension relief was attempted in the transplantation site. Based on the techniques, we have realized scaffold-free 3D regenerative cartilage.

我们生产了由软骨和骨两层组成的复合再生软骨或再生关节，将其应用于唇鼻裂修复或颞下颌关节重建。我们发明的每一种再生软骨，都会产生大量的细胞颗粒，然后赋予它们体力和对缺氧或营养不良的抵抗力。之后，通过将这些颗粒堆积并融合在一起，形成 3D 形状。移植时，尝试在移植部位缓解组织张力。基于该技术，我们实现了无支架3D再生软骨。

项目成果

Inhibition of IGF-1 expression by prolonged TGF-b1 administration suppresses osteoblast differentiation

延长 TGF-b1 给药抑制 IGF-1 表达可抑制成骨细胞分化

• 期刊: J Biol Chem
• 影响因子: 4.8
• 作者: Ochiai H;Okuda S;Saito A;Hoshi K;Yamashita H;Takato T;Azuma T
• 通讯作者: Azuma T

自家軟骨細胞移植の現状と足場材導入による新しい展開

自体软骨细胞移植的现状及支架材料引入的新进展

• 发表时间: 2011
• 作者: Moritani N.;Mishima K.;他6名;7番目;星和人
• 通讯作者: 星和人

DEVELOPMENT OF IMPLANT-TYPE TISSUE-ENGINEERED CARTILAGE APPLIED FOR THE CORRECTION OF THE CLEFT LIP-NOSE PATIENTS

植入式组织工程软骨的开发用于唇裂鼻患者的矫正

• 发表时间: 2011
• 作者: K. Hoshi;Y. Fujihara;S. Nishizawa;Y. Asawa;S. Kanazawa;M. Watanabe;T. Sakamoto;R. Inaki;M. Takei;M. Matsuyama;S. Uto;K. Kurabayashi;M;Harai;T. Ogasawara;S. Nagata;T. Takato
• 通讯作者: T. Takato

生分解性ポリマー足場素材を用いた3次元再生軟骨の研究開発日本再生医療学会雑誌SY-7-4

使用可生物降解高分子支架材料的三维再生软骨的研究与开发 日本再生医学会会刊 SY-7-4

• 发表时间: 2010
• 作者: 星和人;高戸毅
• 通讯作者: 高戸毅

Glial Fibrillary Acidic Protein Maintains Nuclear Morphology And Supports the Resistance to Severe Mechanical Stress in the Chondrocytes of Elastic Cartilage

胶质纤维酸性蛋白维持核形态并支持弹性软骨细胞对严重机械应力的抵抗力

• 发表时间: 2010
• 作者: Kanazawa S;et al.
• 通讯作者: et al.