Minimal reprogramming of cultured MSC based on DNA methylation analysis
Minimal reprogramming of cultured MSC based on DNA methylation analysis
批准号:
23659938
负责人:
HOSHI Kazuto
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
The purpose of this research is to establish safe and reliable technology for regenerative medicine using the cultured mesenchymal stem cells (MSCs), which are reset by minimum reprogramming. In this research, we analyzed DNA methylation of cultured rat MSCs genome-widely, and identified the variations of methylation with cell deterioration. By using stimulus to DNA demethylation,we examined a method to improve the state of the methylation, and applied the method to a bone regeneration model in pig.
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生理活性因子を固定する混合ハイドロゲルと細胞機能向上のための培養方法
固定生物活性因子的混合水凝胶及改善细胞功能的培养方法
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[]
通讯作者:
Feasibility and limitations of the round robin test for assessment of in vitro chondrogenesis evaluation protocol in a tissue-engineered medical product
组织工程医疗产品体外软骨形成评估方案循环试验的可行性和局限性
DOI:
10.1002/term.460
发表时间:
2011
期刊:
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
影响因子:
3.3
作者:
[Masako Yokoi, et al.]
通讯作者:
et al.
et al Administration of the insulin into the scaffold atelocollagen for tissue-engineered cartilage
等人将胰岛素注入组织工程软骨支架去端胶原中
DOI:
--
发表时间:
2011
期刊:
J Biomed Master Res A
影响因子:
--
作者:
[Masako Yokoi, et al., Ko,E.C.]
通讯作者:
Ko,E.C.
OPTIMAL COMBINATIONS OF Innovation of Cartilage Regenerative Medicine by Implant-type Tissue-engineerd Cartilage
植入式组织工程软骨软骨再生医学创新的最佳组合
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Development of implant-type tissue-engineered cartilage applied for the nasal correction of the cleft lip and palate patients
植入式组织工程软骨的研制应用于唇腭裂鼻矫正
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kazuto Hoshi, Yuko Fujihara, Satoru Nishizawa, Yukiyo Asawa, Sanshiro Kanazawa, Makoto Watanabe, Tomoaki Sakamoto, Ryoko Inaki, Misaki Takei, Mariko Matsuyama, Sakura Uto, Kumiko Kurabayashi, Toru Ogasawara,* Satoru Nagata, Tsuyoshi Takato]
通讯作者:
Tsuyoshi Takato
共 30 条
Elucidation of fibrous dysplasia pathogenesis using disease-specific iPS cells and application to drug discovery
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批准号:15K15733
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.25万
-
财政年份:2015
-
负责人:HOSHI Kazuto
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依托单位:
development of functional regenerative bone as a stem cell reserver
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批准号:25670847
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:HOSHI Kazuto
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依托单位:
Identification of stem-ness signal in mesencymal stem cells by mesenchymal-hematopoietic interaction and application to regenerative medicine
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批准号:24390451
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2012
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负责人:HOSHI Kazuto
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依托单位:
Development on scaffold-free 3D regenerative cartilage as surgical implants
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批准号:21390532
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.4万
-
财政年份:2009
-
负责人:HOSHI Kazuto
-
依托单位:
Research to enhance potentials of mesenchymal calls by introducing Nanog gene and its application to regenerative medicine of bone and cartilage
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批准号:18592166
-
项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.93万
-
财政年份:2006
-
负责人:HOSHI Kazuto
-
依托单位:
Molecular mechanisms of cartilage degeneration by mechanical stress
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批准号:18390407
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.43万
-
财政年份:2006
-
负责人:HOSHI Kazuto
-
依托单位:
Research and Development for Fabrication of 3D-structured Tissue-engineered Cartilage through Nino-molecular Technologies
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批准号:16390431
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.22万
-
财政年份:2004
-
负责人:HOSHI Kazuto
-
依托单位:
Development of PIG micelle vector system for gene delivery
-
批准号:14571361
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2002
-
负责人:HOSHI Kazuto
-
依托单位:
海外基金