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Minimal reprogramming of cultured MSC based on DNA methylation analysis

Minimal reprogramming of cultured MSC based on DNA methylation analysis
基于 DNA 甲基化分析的培养 MSC 的最小重编程
批准号:
23659938
负责人:
HOSHI Kazuto
金额:
$2.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
The purpose of this research is to establish safe and reliable technology for regenerative medicine using the cultured mesenchymal stem cells (MSCs), which are reset by minimum reprogramming. In this research, we analyzed DNA methylation of cultured rat MSCs genome-widely, and identified the variations of methylation with cell deterioration. By using stimulus to DNA demethylation,we examined a method to improve the state of the methylation, and applied the method to a bone regeneration model in pig.
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生理活性因子を固定する混合ハイドロゲルと細胞機能向上のための培養方法
固定生物活性因子的混合水凝胶及改善细胞功能的培养方法
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: []
通讯作者:
DOI: 10.1002/term.460
发表时间: 2011
期刊: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
影响因子: 3.3
作者: [Masako Yokoi, et al.]
通讯作者: et al.
et al Administration of the insulin into the scaffold atelocollagen for tissue-engineered cartilage
等人将胰岛素注入组织工程软骨支架去端胶原中
DOI: --
发表时间: 2011
期刊: J Biomed Master Res A
影响因子: --
作者: [Masako Yokoi, et al., Ko,E.C.]
通讯作者: Ko,E.C.
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
30
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