Isolation and identification of oral cancer stem cells and development of specific therapy for cancer stem cells

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The aim of this study is to isolate and identify oral cancer stem cells(CSC) that are considered to be involved in tumor recurrence and metastasis, and to develop the therapy specific for CSC. Various cultured oral squamous carcinoma cells contained SP cells that are included in side population and considered CSC, in 0.04.0.4% of total cell population. The ratio included had a tendency to be increased in cancer cells overexpressing cyclooxygenase-2, cisplatin-resistant cancer cells expressing multidrug resistance gene MDR-1, and cancer cells showing poor differentiation and high invasiveness. There is a possibility to find out a clue for specific therapy by using these CSC-like cells.