Elucidation of the influence that degradation of renal function with aging gives to bone metabolism and periodontal disease

阐明随年龄增长肾功能退化对骨代谢和牙周病的影响

• 批准号: 21390558
• 负责人: YOSHIHARA Akihiro
• 金额: $ 7.07万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390558/
• 关键词: 含公衆衛生学; 栄養学; 歯の喪失; 腎機能低下; 高齢者; 経年調査; 歯周病; 骨代謝; 慢性腎機能低下

This study examined whether low renal function is associated with the bone metabolism and contributing to periodontal disease among community-dwelling elderly Japanese. We selected 674 subjects aged from 55 to 74 years old. Serum cystatin C level was used to assess renal dysfunction. There were significant relationship between serum systatin C level at baseline and the number of remaining teeth or between serum systatin C longitudinal change and the number of missing teeth. In addition, multiple regression analysis showed that the percentage of sites with> 4mm or> 6mm clinical attachment levels was significantly associated with serum osteocalcin levels. Low renal function and reduction of renal function were associated with periodontal disease including tooth loss.

本研究探讨了日本社区老年人肾功能低下是否与骨代谢有关，以及是否与牙周病有关。我们选择了674名受试者，年龄从55岁到74岁。以血清胱抑素C水平评价肾功能损害。基线时血清SYSTAIN C水平与剩余牙数、血清SYSTAIN C纵向变化与缺失牙数均存在显著相关性。此外，多元回归分析显示，临床附着水平> 4mm或> 6mm的位点百分比与血清骨钙素水平显著相关。低肾功能和肾功能下降与牙周病包括牙齿脱落。

项目成果

Association between renal function and tooth loss incommunity-dwelling women

社区女性肾功能与牙齿脱落之间的关系

• 发表时间: 2011
• 作者: Takata Y;TAnsai T;Soh I;Awano S;Yoshitake Y;et al;葭原明弘
• 通讯作者: 葭原明弘

Low renal function and theremaining teeth in postmenopausal women

绝经后妇女的肾功能低下和剩余牙齿

• 发表时间: 2011
• 作者: 竹内祐子;他;A. Yoshihara
• 通讯作者: A. Yoshihara

The association between renal function and tooth loss in Japanese community-dwelling postmenopausal women

日本社区绝经后妇女的肾功能与牙齿脱落之间的关系

• DOI: 10.1111/j.1741-2358.2011.00481.x
• 发表时间: 2011
• 期刊: Gerodontology
• 影响因子: 2
• 作者: A.Yoshihara;et al
• 通讯作者: et al

IV透析と歯周病(1)腎機能と歯周罹患との関連

静脉透析与牙周病（一）肾功能与牙周病的关系

• 发表时间: 2011
• 期刊: 臨床透析
• 作者: 葭原明弘;宮崎秀夫
• 通讯作者: 宮崎秀夫

Low renal function and the remaining teeth in postmenopausal women

绝经后妇女的肾功能低下和剩余牙齿

• 发表时间: 2011
• 作者: Takaharu Sakayori;Yoshinobu Maki;SoIchiro Hirata;Mahito Okada and Takuo Ishii;A.Yoshihara
• 通讯作者: A.Yoshihara