Elucidation of the influence that degradation of renal function with aging gives to bone metabolism and periodontal disease

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This study examined whether low renal function is associated with the bone metabolism and contributing to periodontal disease among community-dwelling elderly Japanese. We selected 674 subjects aged from 55 to 74 years old. Serum cystatin C level was used to assess renal dysfunction. There were significant relationship between serum systatin C level at baseline and the number of remaining teeth or between serum systatin C longitudinal change and the number of missing teeth. In addition, multiple regression analysis showed that the percentage of sites with> 4mm or> 6mm clinical attachment levels was significantly associated with serum osteocalcin levels. Low renal function and reduction of renal function were associated with periodontal disease including tooth loss.