Elucidation of the influence that degradation of renal function with aging gives to bone metabolism and periodontal disease

本研究探讨了低肾功能是否与骨代谢和牙周病有关。我们选择了674名年龄在55 - 74岁之间的受试者。血清胱抑素C水平用于评估肾功能障碍。基线时血清系统抑素C水平与剩余牙数、血清系统抑素C纵向变化与缺失牙数有显著相关。此外，多元回归分析显示，> 4mm或> 6mm临床附着水平的部位百分比与血清骨钙素水平显著相关。肾功能低下和肾功能下降与包括牙齿脱落在内的牙周病有关。

This study examined whether low renal function is associated with the bone metabolism and contributing to periodontal disease among community-dwelling elderly Japanese. We selected 674 subjects aged from 55 to 74 years old. Serum cystatin C level was used to assess renal dysfunction. There were significant relationship between serum systatin C level at baseline and the number of remaining teeth or between serum systatin C longitudinal change and the number of missing teeth. In addition, multiple regression analysis showed that the percentage of sites with> 4mm or> 6mm clinical attachment levels was significantly associated with serum osteocalcin levels. Low renal function and reduction of renal function were associated with periodontal disease including tooth loss.