Search for the epigenetic transcription factor related to fear extinction

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To investigate what the change of DNA methylation in the brain alter behavior, mice were fed with methyl donor deficient diet in their 3wk to 6wk age. Difference in expression of NMDA receptor NR2B subunit in the hippocampus was considered as a cause of the behavioral change after the diet. In human, our results suggested that auditory evoked potential P50 differed according to the cognition of the properties (potentially dangerous or safe) of the perceived signal.