Pathophysiology of basal ganglia disorders analyzed by neuronal recording from mouse models in awake state

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Dystonia is a neurological disorder characterized by sustained or repetitive involuntary muscle contractions and abnormal postures. To understand the pathophysiology of dystonia, neurophysiological analyses were performed on two kinds of mouse models for dystonia in awake state. Abnormal spontaneous neuronal firings of the internal segment of the globus pallidus neurons(GPi) were observed in the mouse models. In addition, motor cortical stimulation evoked abnormal responses of the GPi neurons in the mouse models for dystonia. The results suggest that abnormal firings and cortically evoked response patterns of GPi neurons are participate in the abnormal motor control in dystonia.