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A new index of" cardiac age" derived from echocardiography : A study for brain-cardio-renal connection and organ damages of hypertension.

超声心动图衍生的“心脏年龄”新指标：高血压脑心肾联系与器官损害的研究

基本信息

批准号：
21500447
负责人：
MASUGATA Hisashi
金额：
$ 2.83万
依托单位：
Kagawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2011
项目状态：
已结题

项目摘要

Although pulse wave velocity is the primary indicator of arteriosclerosis and is widely used as an index of vascular age in anti-aging medicine, no index is available to quantify cardiac age. We proposed a" cardiac age" index and sought to clarify its clinical significance. Enrolled in the study were patients with atherosclerosis-related diseases. These patients were divided into normotensive and hypertensive patients. Echocardiography was performed, and brachial-ankle pulse wave velocity(baPWV) was measured using an automatic waveform analyzer. The index of cardiac age was determined as 1000×VSot/ BSA/(VS-AO), where VSot(mm) was the ventricular septal thickness at the left ventricular outflow tract, BSA(m^2) was the body surface area, and VS-AO(degrees) was the angle between the basal ventricular septum and the ascending aorta. The index of cardiac aging correlated significantly with age in both the normotensive and hypertensive patients, and these correlations were closer than those between transmitral E/ A(early to atrial velocity) ratio and age in normotensive and hypertensive patients. The slope between age(x axis) and the index of cardiac age(y axis) was greater in hypertensive(1. 50) than normotensive(1. 32) patients. Stepwise regression analysis showed that age, the presence of hypertension, the left ventricular mass index, the left ventricular end-diastolic dimension, the dimension of left atrium, and the ratio of E to A(E/ A) were independently associated with the index of cardiac age. The index was also significantly correlated with baPWV. The proposed index of cardiac age can quantitatively assess cardiac morphological changes due to aging and/ or hypertension and may be a useful marker of peripheral arterial stiffening.

虽然脉搏波速度是动脉硬化的主要指标，并且在抗衰老医学中被广泛用作血管年龄的指标，但没有可用的指标来量化心脏年龄。我们提出了“心脏年龄”指数，并试图阐明其临床意义。入组研究的患者患有动脉粥样硬化相关疾病。这些患者分为正常血压和高血压患者。进行超声心动图检查，并使用自动波形分析仪测量臂踝脉搏波速度（baPWV）。心脏年龄指数确定为1000×VSot/ BSA/（VS-AO），其中VSot（mm）为左心室流出道室间隔厚度，BSA（m^2）为体表面积，VS-AO（度）为室间隔基底部与升主动脉之间的角度。正常血压组和高血压组的心脏老化指数与年龄均呈显著相关，且与年龄的相关性比正常血压组和高血压组的二尖瓣E/ A（Early to Atrial Velocity，E/A）比值更密切。年龄（x轴）和心脏年龄指数（y轴）之间的斜率在高血压患者中更大（1。50)血压正常者（1. 32)患者逐步回归分析显示年龄、高血压、左室重量指数、左室舒张末期内径、左房内径、E/A与心脏年龄指数独立相关。该指数也与baPWV显著相关。心脏年龄的建议指数可以定量评估心脏形态学变化，由于老化和/或高血压，并可能是一个有用的标记外周动脉硬化。