Evaluation of visco-elasticity of local arterial wall using M-mode intravascular ultrasound

M型血管内超声评价局部动脉壁粘弹性

• 批准号: 08670796
• 负责人: MASUGATA Hisashi
• 金额: $ 1.41万
• 依托单位: Kagawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670796/
• 关键词: M-mode intravascular ultrasound; Aging; Arterial wall; Visco-elasticity; Coronary artery; Plaque; Elastic fiber; Collagen fiber

1.Development of M-mode intravascular ultrasound imaging system :In order to depict arbitrary directional M-mode images of arterial wall using intravascular ultrasound, we developed an omni-directional M-mode intravascular ultrasound system. A 1mm x 1mm ultrasound transducer with 30 MHz center frequency, is mounted at the tip of catheter, and the M-mode arterial wall images are depicted in arbitrary direction. The resolution is 0.15mm. In addition, we can gain almost real time two-dimensional images of the arterial wall by the system.Assessment of stiffness of human arterial wall by M-mode intravascular ultrasound :We evaluated local arterial wall elastic property based on the relationship between instantaneous arterial wall thickness during cardiac cycle measured by M-mode intravascular ultrasound and simultaneous intraluminal pressure. In human, arterial stiffness increased after branching of the renal artery and increased greatly towards the periphery. In addition, human arterial wall stiffness increased with advancing age. These findings were related to an increase of wall thickness/luminal ratio, which may reflect a morphological change in the artery associated with the progression of arteriosclerosis.

1.M型血管内超声成像系统的研制：为了利用血管内超声描绘动脉壁任意方向的M型图像，我们开发了全向M型血管内超声系统。中心频率为 30 MHz 的 1mm x 1mm 超声换能器安装在导管尖端，可在任意方向描绘 M 模式动脉壁图像。分辨率为0.15mm。此外，我们可以通过该系统获得几乎实时的动脉壁二维图像。 通过M型血管内超声评估人体动脉壁的硬度：我们根据M型血管内超声测量的心动周期中瞬时动脉壁厚度与同时管腔内压力之间的关系来评估局部动脉壁的弹性特性。在人类中，肾动脉分支后动脉硬度增加，并且朝外周大大增加。此外，人体动脉壁硬度随着年龄的增长而增加。这些发现与壁厚度/管腔比的增加有关，这可能反映了与动脉硬化进展相关的动脉形态变化。

项目成果

Mizushige Katsufumi: "Effects of short-term administration of sublingual nifedipine on coronary arterial wall elastic properties:Evaluation by intravascular ultrasound" J Cardiovasc Pharmacol. 29(4). 508-514 (1997)

Mizushige Katsufumi：“短期舌下含服硝苯地平对冠状动脉壁弹性的影响：血管内超声评估”J Cardiovasc Pharmacol。

Morita Hisaki: "A new noninvasive method of diagnosing vasospastic angina based on dilation response of the left main coronary artery to nitroglycerin as measured by echocardiograpy" J Am Coll Cardiol. 27(6). 1450-1457 (1996)

Morita Hisaki：“一种基于超声心动图测量的左主冠状动脉对硝酸甘油的扩张反应来诊断血管痉挛性心绞痛的新无创方法”J Am Coll Cardiol。

Morita Hisaki: "A new noninvasive method of diagnosing vasospastic angina based on delation response of the left main coronary artery to nitroglycerin as measured by echocardiograpy." J Am Coll Cardiol. 27(6). 1450-1457 (1996)

Morita Hisaki：“一种诊断血管痉挛性心绞痛的新无创方法，基于超声心动图测量的左冠状动脉主干对硝酸甘油的延迟反应。”