Novel ion channel analogues by peptide nanotubes containing fluorinated amino acids

通过在多肽中引入氟化的-氨基酸，对-多肽的二级结构进行了简单的控制。我们的成果包括：(1)大规模不对称合成对映纯氟化β -氨基酸；(2)建立了氟化β -氨基酸的肽延伸；(3)氟化β -氨基酸在肽工程中的应用。

Facile control of the secondary structure of beta-peptides was attempted, by introducing fluorinated beta-amino acids in the peptides. Our achievements include (1) large-scale asymmetric synthesis of enantiopure fluorinated beta-amino acids, (2) establishing the peptide elongation of fluorinated beta-amino acids, and (3) application of fluorinated beta-amino acids to peptide engineering.