Structural and Functional Regulation of Saccharide-Recognizing Polymers by Rotaxane Formation

轮烷形成对糖识别聚合物的结构和功能调控

• 批准号: 21750139
• 负责人: ABE Hajime
• 金额: $ 2.83万
• 依托单位: University of Toyama
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21750139/
• 关键词: らせん; 円二色性; 糖認識; ロタキサン; 協同効果

Our group has developed ethynylpyridine polymers as saccharide recognizing host polymers. In this study, new types of ethynylpyridine polymers bearing side chains with host ability were developed in order to regulate the higher-order helical structure and saccharide recognition ability of the polymers.Two classes of ethynylpyridine polymers could be prepared, one is polymer with azacrown side chains and the other is polymer with acyclic azaether side chains. Azacrown-introduced polymers showed helix stabilization and positive allosterism for saccharide recognition by the addition of oligoammonium additives as axles of rotaxane. Azaether-introduced polymers also showed helix stabilization by the addition of Cu(II) cations which coordinate with the chelating side chains.

我们的团队开发了乙炔基吡啶聚合物作为糖识别宿主聚合物。在本研究中，为了调节聚合物的高阶螺旋结构和对糖的识别能力，开发了新型的具有宿主能力的含侧链的乙炔基吡啶聚合物，可以制备两类乙炔基吡啶聚合物，一类是带有氮杂冠醚侧链的聚合物，另一类是带有无环氮杂醚侧链的聚合物。氮杂冠醚引入的聚合物通过添加低聚铵盐添加剂作为轮烷的轴，表现出螺旋稳定和正变构识别糖的作用。氮杂醚引入的聚合物也通过添加与螯合侧链配位的铜(II)阳离子而显示出螺旋稳定性。

项目成果

Inouye Saccharide Recognition of Poly(meta-ethynylpyridine)s Regulated by Pseudorotaxane Formation 5th International Symposium on Macrocyclic and Supramolecular Chemistry

拟轮烷形成调控的聚(间乙炔基吡啶)的Inouye糖识别第五届大环与超分子化学国际研讨会

• 发表时间: 2010
• 作者: S. Takashima;H. Abe;M. Inouye
• 通讯作者: M. Inouye

Copper(II)-mediated chiral helicity amplification and inversion of meta-ethynylpyridine polymers with metal coordination sites

铜(II)介导的具有金属配位点的间乙炔基吡啶聚合物的手性螺旋放大和反转

• 发表时间: 2011
• 期刊: Chem.Commun. in press
• 作者: Takashima;S.; Abe;H.; Inouye;M.
• 通讯作者: M.

Inouye Molecular Nut Based on Ethynylpyridine Oligomers 5th International Symposium on Macrocyclic and Supramolecular Chemistry

Inouye 基于乙炔基吡啶低聚物的分子坚果第五届国际大环与超分子化学研讨会

• 发表时间: 2010
• 作者: F. Kayamori;H. Abe;M. Inouye
• 通讯作者: M. Inouye

銅イオン添加によるエチニルピリジンポリマーの糖認識制御

通过添加铜离子控制乙炔基吡啶聚合物中的糖识别

• 发表时间: 2010
• 作者: 赤木友紀;石原俊也;藤井健太;松永拓郎;勝本之晶;柴山充弘;鄭雄一;酒井崇匡;Takuya Terai;Kenji Nakamura et al.;金子芳郎;高嶋俊輔・阿部肇・井上将彦
• 通讯作者: 高嶋俊輔・阿部肇・井上将彦

Inouye Fixation of Chiral Helical Structure of Saccharide-Recognizing Polymer

糖识别聚合物手性螺旋结构的井上固定

• 发表时间: 2010
• 作者: H. Abe;F. Kayamori;M. Inouye
• 通讯作者: M. Inouye