Structural and Functional Regulation of Saccharide-Recognizing Polymers by Rotaxane Formation

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Our group has developed ethynylpyridine polymers as saccharide recognizing host polymers. In this study, new types of ethynylpyridine polymers bearing side chains with host ability were developed in order to regulate the higher-order helical structure and saccharide recognition ability of the polymers.Two classes of ethynylpyridine polymers could be prepared, one is polymer with azacrown side chains and the other is polymer with acyclic azaether side chains. Azacrown-introduced polymers showed helix stabilization and positive allosterism for saccharide recognition by the addition of oligoammonium additives as axles of rotaxane. Azaether-introduced polymers also showed helix stabilization by the addition of Cu(II) cations which coordinate with the chelating side chains.