Establishment of In Vivo Non-Destructive and Less-Invasive method for Analyzing Bone Quality

对于提取的骨骼（离体），使用带有透射光学系统的微束x射线衍射技术成功地定量分析了生物磷灰石的首选取向。根据骨组织的x射线吸收系数和骨形态对分析条件进行优化。为了将该技术扩展到体内（非提取）骨骼，采用x射线吸收谱来检测软组织内的骨骼。通过结合这些技术，可以检测骨骼并获得体内骨骼的x射线衍射信息。这意味着本研究建立了一种体内无损、微创的骨质量分析方法。

For extracted bones (ex vivo), quantitative analysis of the preferred orientation of biological apatite was successfully achieved by using a microbeam X-ray diffraction technique with a transmission optical system. The analytical condition was optimized based on the X-ray absorption coefficient of bone tissue and bone morphology. To expand this technique for in vivo (non-extracted) bone, X-ray absorption profile was taken for the detection of bone totally inside of soft tissues. By combining these techniques, it was possible to detect bone and obtain X-ray diffraction information from bone in vivo. This means the in vivo non-destructive and less-invasive method for analyzing bone quality was established in this study.