Artificial control of bone mechanical functions usingmagnesium as a biological trace metal

使用镁作为生物微量金属人工控制骨机械功能

• 批准号: 23760669
• 负责人: ISHIMOTO Takuya
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23760669/
• 关键词: 生体微量金属元素; マグネシウム; 骨質; 生体アパタイト; 結晶学的配向性; in vivo; in vitro; 結晶配向性; 骨力学機能; コラーゲン; 配向性; 微小領域X線回折法; 結晶成長

The effects of magnesium as a biological trace metal on the preferential orientation of bone apatite were elucidated using in vivo (animal model)and in vitro(apatite synthesis) systems. Degree of the preferential apatite c-axis orientation along the long axis in a rat long bone significantly changed along with the administration of a magnesium-deficient diet. In the in vitroapatite synthesis through a wet process, the degree of the preferential apatite orientation varied as a function of the magnesium ion/calcium ion ratio (Mg2+/Ca2+) despite the collagen alignment used as a template for the apatite formation was constant. The orientation degree peaked at the specific Mg2+/Ca2+; the peak value was comparable to that in the rat femur. The results indicate that the biological trace metals affect the degree of epitaxy between collagen and apatite c-axis, and finally control the apatite orientation which predominate the bone mechanical functions. The potential of the biological trace metals on the control of the apatite orientation and the resultant mechanical functions was demonstrated.

使用体内（动物模型）和体外（磷灰石合成）系统阐明镁作为生物痕量金属对骨磷灰石优先取向的影响。大鼠长骨中长轴沿长轴的优先磷灰石C轴取向的程度随着镁缺陷饮食的给药而发生了明显变化。在通过湿过程的体外磷灰石合成中，尽管胶原蛋白比对被用作磷灰石形成的模板，但优先磷灰石方向的程度随镁离子/钙离子比（Mg2+/Ca2+）而变化。方向度在特定的Mg2+/Ca2+上达到峰值；峰值与大鼠股骨相当。结果表明，生物痕量金属会影响胶原蛋白和磷灰石C轴之间的外延程度，并最终控制占主导骨骼机械功能的磷灰石方向。展示了生物痕量金属在控制磷灰石方向以及所得机械功能的潜力。

项目成果

Competitive change in bone mass, bone density, and preferred orientation of biological apatite in unloaded rat femur by sciatic-neurectomy

坐骨神经切除术对大鼠股骨卸荷后骨量、骨密度和生物磷灰石择优取向的竞争性变化

• 发表时间: 2011
• 作者: J. Wang;T. Ishimoto;T. Nakano
• 通讯作者: T. Nakano

骨微細構造・力学機能に対する生体微量金属元素の影響

生物微量金属元素对骨微结构和力学功能的影响

• 发表时间: 2012
• 作者: 石本卓也;大路博;中野貴由
• 通讯作者: 中野貴由

Adavanced analysis and control of bone microstructure based on a materials scientific study including microbeam X-ray diffraction, Progress in Advanced Structural and Functional Materials Design

基于包括微束 X 射线衍射在内的材料科学研究的骨微结构的高级分析和控制，先进结构和功能材料设计的进展

• 发表时间: 2012
• 作者: T. Nakano;T. Ishimoto;N. Ikeo;A. Matsugaki
• 通讯作者: A. Matsugaki

Quick recovery in preferential orientation of biological apatite and related mechanical function during bone regeneration by running exercise

跑步运动促进骨再生过程中生物磷灰石择优取向及相关机械功能的快速恢复

• 发表时间: 2012
• 期刊: Japanese Journal of Clinical Biomechanics
• 作者: T. Ishimoto;Y. Yoshida;T. Nakano
• 通讯作者: T. Nakano

Regeneration of bone mass and bone quality around implant with grooves for aligning bone cells in rabbit hindlimb bone

兔后肢骨中带有凹槽的植入物周围骨量和骨质量的再生，用于对齐骨细胞

• DOI: 10.4028/www.scientific.net/msf.706-709.510
• 发表时间: 2012
• 期刊: Materials Science Forum
• 作者: T. Ishimoto;K. Kawata;T. Sakai;H. Yoshikawa and T. Nakano
• 通讯作者: H. Yoshikawa and T. Nakano