The role of SOG1, a novel transcription factor, in the DNA damage checkpoint

DNA可受到细胞外和细胞间的损伤，如电离辐射、某些化学试剂和活性氧。受损的DNA必须修复，以防止遗传信息的丢失或错误传递。因此，真核细胞具有DNA检查点系统，该系统在DNA受损或复制不完全时阻止细胞周期，为细胞在进入有丝分裂前修复受损的染色体提供时间。本课题旨在明确植物特异性DNA检查点系统的机制。因此，我们发现SOG1在DNA检查点中起重要作用，SOG1在根尖分生组织和茎尖分生组织中起作用，SOG1蛋白在DNA损伤时被修饰。

DNA can be damaged by extracellular and intercellular insults such as ionizing radiation, some chemical agents and reactive oxygen species. The damaged DNA must be repaired to prevent loss or incorrect transmission of genetic information. Therefore, eukaryotic cells have DNA checkpoint system, which arrests the cell cycle in response to damaged or incompletely replicated DNA to provide time for the cell for repair damaged chromosome before entering mitosis. The purpose of this project is to make clear the mechanism of plant specific DNA checkpoint system. As a result, we showed that SOG1 plays an important role in DNA checkpoint, SOG1 functions at the root apical meristems and the shoot apical meristems, and SOG1 protein is modified in response to DNA damage.