Analysis of the infuluence of physiological and morphological variability to the synaptic integration of a nonspiking interneuron

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The present study aimed to investigate the influence of physiological morphological variability to the synaptic integration (synaptic output) of an identified nonspiking interneuron (LDS neuron) using neurophysiological and computational methods. In 2009, in order to quantify the variability of the membrane conductance of dendrite and three-dimensional structure of the LDS cells, their membrane conductances were investigated neurophysiologically and neuropharmacologically and their three-dimensional structures were measured using a laser scanning microscope. The result shows large variability of the membrane conductance across the cells. However, the morphology of the cell could not be obtained while the membrane conductance was recorded at the same time using cell filling fluorescent dye, Lucifer Yellow so that three dimensional structures of the cells could not be quantified from the cell recorded electrophysiologically. In 2010, three types of membrane conductances in the LDS cell was estimated quantatively.