Peptidomics-based mining of novel antimicrobial peptides

近年来，医院细菌耐药问题日益突出。有效对抗这些细菌的候选物之一是抗微生物肽。本研究的目的是利用肽组学分析从已鉴定的肽中发现新的抗菌肽。我们根据抗菌活性对它们进行了筛选，发现了包括AMP-IBP 5在内的两个新的抗菌肽。AMP-IBP 5是分子内二硫键连接的22个残基酰胺化肽。该肽具有比β-防御素-2更强的抗菌活性，有望成为新药的候选者。

Recently, it has been an increasing problem of drug-resistant bacteria in a hospital. One of candidates effective against these bacteria is an antimicrobial peptide. This study was aimed at discovery of novel antimicrobial peptides from identified peptides using peptidomic analysis. We screened them based on antimicrobial activity and found two novel antimicrobial peptides including AMP-IBP5. AMP-IBP5 is an intramolecular disulfide-linked 22-residue amidated peptide. This peptide showed antimicrobial activity stronger than β-defensin-2 and could become candidates for new drugs.