Single molecular analysis of sumoylation-dependent chromatin remodeling factor

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The small ubiquitin-like modifier (SUMO) conjugates transcription factors, and suppresses the transcription of their target genes. Although various SUMO-conjugated transcription factors have been isolated, mechanisms how sumoylated-transcription factors suppress transcription remain largely unknown. To understand mechanisms of SUMO-dependent transcriptional repression, we purified interacting partners for a nuclear receptor and identified ARIP4 known as a SNF2 chromatin-remodeling factor.