Analysis of molecular mechanisms of the formation of the intercellular junction-underlying actin bundle using semi-intact epithelium.

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Epithelial sheets play important roles in morphogenesis of multicellular organisms. So far, it has been unknown how the intercellular junction-underlying actin cytoskeleton are formed. In this study, I showed that ArhGEF11, a guanine nucleotide exchange factor of the small GTPase RhoA, is localized at the cell-cell-junction and that ArhGEF11 is required for the formation of the actin cytoskeleton vertical to cell-cell junction during the formation process of cell-cell junction.