MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

MicroRNA-9 通过靶向多种转录因子调节小鼠端脑的神经发生

• 批准号: 21770248
• 负责人: SHIBATA Mikihito
• 金额: $ 2.91万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770248/
• 关键词: マウス; 発生; 端脳; 大脳新皮質; microRNA-9; Foxg1; Cajal-Retzius cells; corticogenesis; subcorticogenesis; Gsh2; Brn2; Meis2; Islet1; 細胞増殖; TCA

microRNA-9-2 and microRNA-9-3 double-mutant mice demonstrate that microRNA-9 (miR-9) controls neural progenitor proliferation and differentiation in the developing telencephalon by regulating the expression of multiple transcription factors. Also we found that the activity of miR-9 is finely modulated by AU-rich RNA-binding proteins and Msi1 during development.

microRNA-9-2和microRNA-9-3双突变小鼠证明，microRNA-9（miR-9）通过调节多种转录因子的表达来控制发育中端脑中神经祖细胞的增殖和分化。我们还发现，miR-9的活性在发育过程中受到富含AU的RNA结合蛋白和Msi 1的精细调节。

项目成果

microRNA-9 is required for neurogenesis and axon pathfinding in mouse telencephalon through the regulation of Foxg1, Nr2e1, Gsh2, Meis2, and Islet1

通过调节 Foxg1、Nr2e1、Gsh2、Meis2 和 Islet1，microRNA-9 是小鼠端脑神经发生和轴突寻路所必需的

• 发表时间: 2010
• 作者: Mikihito Shibata;Hiromi Nakao;Hiroshi Kiyonari;Takaya Abe;Shinichi Aizawa
• 通讯作者: Shinichi Aizawa

microRNA-9 is regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2, Meis2, and Islet1

microRNA-9 通过靶向 Foxg1、Nr2e1、Gsh2、Meis2 和 Islet1 调节大脑皮层和大脑皮层下的神经祖细胞增殖和分化

• 发表时间: 2010
• 作者: Mikihito Shibata;Hiromi Nakao;Hiroshi Kiyonari;Takaya Abe;Shinichi Aizawa
• 通讯作者: Shinichi Aizawa

MicroRNA-9 targets Foxg1, Nr2e1, and Meis2 for neurogenesis in mouse telencephalon

MicroRNA-9 靶向 Foxg1、Nr2e1 和 Meis2 促进小鼠端脑神经发生

• 发表时间: 2010
• 作者: Koji Terada;Takahisa Furukawa;柴田幹士
• 通讯作者: 柴田幹士

MicroRNA-9 Regulates Neurogenesis in Mouse Telencephalon by Targeting Multiple Transcription Factors

• DOI: 10.1523/jneurosci.5085-10.2011
• 发表时间: 2011-03-02
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Shibata, Mikihito;Nakao, Hiromi;Aizawa, Shinichi
• 通讯作者: Aizawa, Shinichi

MicroRNA-9 regulates neural progenitor proliferation and differentiation in both pallium and subpallium by targeting Foxg1, Nr2e1, Gsh2 and Meis2

• DOI: 10.1016/j.ydbio.2010.05.440
• 发表时间: 2010-08
• 期刊: Developmental Biology
• 影响因子: 2.7
• 作者: M. Shibata;Hiromi Nakao;H. Kiyonari;T. Abe;S. Aizawa