Mechanisms of the PCP signal transduction to bend neuroepithelial layer

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Neural tube is the precursor of the central nervous system, andformed by the bending of the neural plate along the body axis, although underlying mechanisms were not completely understood. We found that at the apical cell-cell contact sites of the neuroepithelial cells, which constitute neural plate, actomyosin cytoskeleton is activated and contracted in the direction perpendicular to the body axis, leading to a tube formation. Furthermore, we uncovered a novel signaling pathway in which the planar cell polarity signaling regulates the polarized activation of actomyosin in the bending neural plate.