The association among folate intakes, homocysteine and atherosclerosis.

叶酸摄入量、同型半胱氨酸和动脉粥样硬化之间的关联。

• 批准号: 21770267
• 负责人: NAKAZATO Mio
• 金额: $ 2.83万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770267/
• 关键词: 葉酸; 動脈硬化; 頸動脈内中膜複合体厚; 心臓足首血管指数; ホモシステイン; 離島; へき地; 頸動脈内中膜複合体; 赤血球中葉酸

This study was investigated the association among homocysteine, folate, methylene-tetrahydrofolate reductase gene C677Tpolymorphism, and clinical evaluations of atherosclerosis on three remote islands with different populations. Although homocysteine reversely correlated to folate, homocysteine or folate were not correlate to clinical evaluations of atherosclerosis. The homocysteine has lower values in island with less population, and it has divergence among homocysteine, serum folate and erythrocyte folate values. They are suggested that homocysteine were affected by environmental factors excluding MTHFR gene polymorphism or folate intake, and erythrocyte folate was better than serum folate as indicator of folate status.

本研究调查了同型半胱氨酸、叶酸、亚甲基四氢叶酸还原酶基因C677T多态性与三个不同人口的偏远岛屿动脉粥样硬化的关系。尽管同型半胱氨酸与叶酸呈负相关，但同型半胱氨酸或叶酸与动脉粥样硬化的临床评估无关。同型半胱氨酸值在人口较少的岛屿较低，在同型半胱氨酸、血清叶酸和红细胞叶酸值之间存在差异。提示同型半胱氨酸水平受环境因素的影响，不包括MTHFR基因多态性和叶酸摄入量，红细胞叶酸比血清叶酸更能反映叶酸状态。

项目成果

健診受診者3,908名における、内膜中膜複合体厚(IMT)と心臓足首血管指数(CAVI)に影響を与える因子の検討

3,908名健康体检者的内膜中层复合体厚度（IMT）和心踝血管指数（CAVI）影响因素调查

• 发表时间: 2011
• 作者: 中里未央;関田孝晴;江村康介;門田耕一郎;和田光弘;前田隆浩;太田幹也
• 通讯作者: 太田幹也

The association between atherosclerosis and plasma homocysteine concentration in the general population residing on remote islands in Japan

日本偏远岛屿普通人群的动脉粥样硬化与血浆同型半胱氨酸浓度之间的关系

• 发表时间: 2011
• 期刊: ACTA MEDICA NAGASAKIENSIA
• 作者: Nakazato M;Takamura N;Kadota K;Yamasaki H;Mukae H;Kusano Y;Nakashima K;Ozono Y;Aoyagi K;Kohno S;Maeda T
• 通讯作者: Maeda T

Relation of body mass index to blood folate and total homocysteine concentrations in Japanese adults

• DOI: 10.1007/s00394-010-0165-0
• 发表时间: 2011-10-01
• 期刊: EUROPEAN JOURNAL OF NUTRITION
• 影响因子: 5
• 作者: Nakazato, Mio;Maeda, Takahiro;Tamura, Tsunenobu
• 通讯作者: Tamura, Tsunenobu

Indices of atherosclerosis in relation to total homocysteine and blood folate levels in Japanese adults

日本成年人动脉粥样硬化指数与总同型半胱氨酸和血液叶酸水平的关系

• 发表时间: 2010
• 作者: M. Nakazato;T. Maeda N. Takamura;K. Kadota;K. Nakashima and T. Tamura
• 通讯作者: K. Nakashima and T. Tamura

Relationship Between Periodontal Status and HbA1c in Nondiabetics

• DOI: 10.1111/j.1752-7325.2009.00122.x
• 发表时间: 2009-06-01
• 期刊: JOURNAL OF PUBLIC HEALTH DENTISTRY
• 影响因子: 2.3
• 作者: Hayashida, Hideaki;Kawasaki, Koji;Saito, Toshiyuki
• 通讯作者: Saito, Toshiyuki