The association among folate intakes, homocysteine and atherosclerosis.

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This study was investigated the association among homocysteine, folate, methylene-tetrahydrofolate reductase gene C677Tpolymorphism, and clinical evaluations of atherosclerosis on three remote islands with different populations. Although homocysteine reversely correlated to folate, homocysteine or folate were not correlate to clinical evaluations of atherosclerosis. The homocysteine has lower values in island with less population, and it has divergence among homocysteine, serum folate and erythrocyte folate values. They are suggested that homocysteine were affected by environmental factors excluding MTHFR gene polymorphism or folate intake, and erythrocyte folate was better than serum folate as indicator of folate status.