Development of new synthetic methodology based on Conia-ene type cyclization

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The key intermediate for the synthesis of omuralide was obtained via conia-ene cyclization followed by ozonolysis ,reduction with NaBH4, silylation, and stereoselective reduction of geminal esters.Synthetic study on cinatrin C1 was investigated starting from 1-benzyl oxy-(S)-but-3-yne-2-ol. O-H insertion by dizazo malonic ester and following Conia-ene reaction gave Key THF ring intermediate. Dihydroxylation followed by lactone formation, stereoselective reduction of geminal ester, DIBAL reduction and Wittig reaction gave crutial crucial intermediate. Formation of lactone ring by oxidation of THF ring is under investigation.