Elucidation of regulatory mechanisms for cancer cell proliferation and malignancies by microRNA in esophageal squamous cell carcinoma

食管鳞状细胞癌中 microRNA 阐明癌细胞增殖和恶性肿瘤的调节机制

• 批准号: 21790072
• 负责人: TSUCHIYA Soken
• 金额: $ 2.41万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790072/
• 关键词: 細胞増殖制御メカニズム; microRNA; 食道扁平上皮癌; 細胞増殖; 悪性度; 創薬

Here, we reports that the expression of microRNA-210 (miR-210) is downregulated in human esophageal squamous cell carcinoma (ESCC) and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. We found that miR-210 inhibits cancer cell survival and proliferation by inducing cell death and cell cycle arrest in G1/G0 and G2/M. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target of miR-210 in ESCC, and demonstrated that FGFRL1 accelerates cancer cell proliferation by preventing cell cycle arrest in G1/G0. Taken together, our findings show an important role for miR-210 as a tumor suppressive microRNA with effects on cancer cell proliferation.

在此，我们报告了microRNA-210（miR-210）在人食管鳞状细胞癌（ESCC）及其衍生细胞系中的表达下调。miR-210水平显著降低，尤其是在低分化癌中。我们发现miR-210通过诱导细胞死亡和细胞周期停滞在G1/G 0和G2/M期来抑制癌细胞的存活和增殖。最后，我们确定了成纤维细胞生长因子受体样1（FGFRL 1）作为ESCC中miR-210的靶点，并证明FGFRL 1通过阻止G1/G 0期细胞周期停滞加速癌细胞增殖。综上所述，我们的研究结果表明miR-210作为肿瘤抑制microRNA对癌细胞增殖具有重要作用。

项目成果

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miR-210 regulates cancer cell proliferation through targeting FGFRL1.

miR-210 通过靶向 FGFRL1 来调节癌细胞增殖。

• 发表时间: 2010
• 作者: Tsuchiya S.;Fujiwara T.;Sato F.;Tsujimoto G.;Shimizu K.
• 通讯作者: Shimizu K.

MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1)

• DOI: 10.1074/jbc.m110.170852
• 发表时间: 2011-01-07
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Tsuchiya, Soken;Fujiwara, Takeshi;Tsujimoto, Gozoh
• 通讯作者: Tsujimoto, Gozoh

miR-210による新規標的遺伝子RAB26の翻訳阻害は食道扁平上皮癌の細胞増殖を抑制する

miR-210抑制新靶基因RAB26翻译抑制食管鳞癌细胞增殖

• 发表时间: 2011
• 作者: 土屋創健;佐藤史顕;嶋田裕;辻本豪三;清水一治
• 通讯作者: 清水一治

miR-X Contributes to Cisplatin Resistance of Esophageal Cancer cells

miR-X 导致食管癌细胞顺铂耐药

• 发表时间: 2009
• 作者: Yodoi R;Tamba S;Morimoto K;Segi-Nishida E;Nishihara M;Ichikawa A;Narumiya S;Sugimoto Y.;今中由花子
• 通讯作者: 今中由花子