Elucidation of regulatory mechanisms for cancer cell proliferation and malignancies by microRNA in esophageal squamous cell carcinoma

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Here, we reports that the expression of microRNA-210 (miR-210) is downregulated in human esophageal squamous cell carcinoma (ESCC) and derived cell lines. Marked decreases in the level of miR-210 were observed especially in poorly differentiated carcinomas. We found that miR-210 inhibits cancer cell survival and proliferation by inducing cell death and cell cycle arrest in G1/G0 and G2/M. Finally, we identified fibroblast growth factor receptor-like 1 (FGFRL1) as a target of miR-210 in ESCC, and demonstrated that FGFRL1 accelerates cancer cell proliferation by preventing cell cycle arrest in G1/G0. Taken together, our findings show an important role for miR-210 as a tumor suppressive microRNA with effects on cancer cell proliferation.