The effect of physiological antidepressant treatments on the gene expression pattern in hypothalamic nuclei

生理性抗抑郁治疗对下丘脑核团基因表达模式的影响

• 批准号: 21790074
• 负责人: SEGI Eri
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790074/
• 关键词: 精神分子薬理学; 抗うつ治療; 遺伝子発現; 視床下部; うつ病; 電気けいれん療法; マイクロアレイ解析; 遺伝子発現変化; 脳神経疾患; マイクロアレイ; 遺伝子; 神経科学; ストレス

The exact mechanisms underlying the actions of physiological antidepressant treatment (electroconvulsive therapy) are not yet understood. To identify the gene expression changes by antidepressant treatments in the paraventricular nucleus of hypothalamus (PVN), microarray analysis was performed. I identified several genes as differentially regulated in PVN by electroconvulsive therapy. Although the involvement of the identified gene products in antidepressant effects still remains unknown, some of down-regulated genes, such as protein kinase C and neuropeptide Y, have been reported their relevance to psychological disorders.

生理性抗抑郁治疗（电惊厥治疗）的确切机制尚不清楚。为了确定下丘脑室旁核（PVN）抗抑郁治疗引起的基因表达变化，进行了微阵列分析。我发现了几个基因在 PVN 中受到电休克治疗的差异调节。尽管已鉴定的基因产物在抗抑郁作用中的作用仍不清楚，但一些下调基因，如蛋白激酶 C 和神经肽 Y，已被报道与心理障碍相关。

项目成果

アレルギー性喘息・うつ病を中心とする病態・治療基盤の分子メカニズム研究

研究病理状况和治疗的分子机制，主要是过敏性哮喘和抑郁症。

• 发表时间: 2010
• 作者: 山口賀章;溝曽路祥孝;岡村均;瀬木(西田)恵里(発表者)
• 通讯作者: 瀬木(西田)恵里(発表者)

RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.

卵丘中的 RhoA/Rho 激酶信号传导介导细胞外基质组装。

• 发表时间: 2009
• 期刊: Endocrinology.
• 作者: Yodoi R;Tamba S;Morimoto K;Segi-Nishida E;Nishihara M;Ichikawa A;Narumiya S;Sugimoto Y.
• 通讯作者: Sugimoto Y.

Exploration of new molecular mechanisms for antidepressant actions of electroconvulsive seizure.

• DOI: 10.1248/bpb.34.939
• 发表时间: 2011-07
• 期刊: Biological & pharmaceutical bulletin
• 影响因子: 2
• 作者: E. Segi-Nishida

Gene profile of electroconvulsive seizures of the paraventricular nucleus of hypothalamus

下丘脑室旁核电惊厥发作的基因谱

• 发表时间: 2010
• 作者: 瀬木(西田)恵里(発表者);他
• 通讯作者: 他

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

• DOI: 10.1073/pnas.0915112107
• 发表时间: 2010-07-06
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Esaki, Yoshiyasu;Li, Youxian;Narumiya, Shuh
• 通讯作者: Narumiya, Shuh