The exploration of antidepressant effects in the hypothalamic nuclei

本研究的目的是探讨电惊厥发作（ECS）在下丘脑核团的抗抑郁作用。(1)ECS下调室旁下丘脑胆囊收缩素的基因表达，胆囊收缩素被认为是应激反应的调节剂。(2)ECS上调腹内侧下丘脑促氧化因子的基因表达，并通过腹内侧下丘脑功能减少食物摄入。本研究表明ECS在调节能量稳态中的作用。

The purpose of the study is to explore antidepressant effects of electroconvulsive seizures (ECS) in the hypothalamic nuclei.(1) ECS down-regulates gene expression of cholecystokinin, which is suggested as a modulator of the stress responses, in the paraventricular hypothalamus.(2) ECS up-regulates gene expression of anorexigenic factors in the ventromedial hypothalamus, and decreases food intake via ventromedial hypothalamus function. This study suggests a role in the regulation energy homeostasis by ECS.