The study of toxic mechanisms of dioxins using selenium-binding protein deficient mouse.

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The biological roles of dioxin-inducible selenium-binding protein (SeBP) remain controversial. To address this issue, the SeBP-deficient mice were developed. The notable differences of phenotype and growth curve were not observed between wild-type and SeBP-deficient mice. However, the ovary weight in adult SeBP-deficient mice was significantly increased compared with that in adult wild-type mice. Thus, it is suggested that SeBP is one of suppressive factors of ovary tumor occurred with aging.