Epigenetic regulation of CYP3A4 gene and individual phenotypic status

CYP3A4基因的表观遗传调控与个体表型状态

• 批准号: 21790151
• 负责人: HIROTA Takeshi
• 金额: $ 2.83万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790151/
• 关键词: エピジェネティクス; 発現制御; 薬物代謝酵素; バイオマーカー

We show that DNA methylation in CYP3A4 enhancer region is critically involved in determining the individual hepatic CYP3A4 mRNA level. Chromosome Conformation Capture assay suggested long-range cis-interaction between the enhancer region and the transcription start site.

我们发现CYP3A4增强子区域的DNA甲基化是决定个体肝脏CYP3A4 mRNA水平的关键因素。染色体构象捕获分析表明增强子区域和转录起始位点之间存在长程顺式相互作用。

项目成果

Interindividual differences in placental expression of the SLC22A2(OCT2)gene: Relationship to epigenetic variations in the 5'-upstream regulatory region.Journal of Pharmaceutical Sciences

SLC22A2(OCT2)基因胎盘表达的个体差异：与5上游调控区表观遗传变异的关系。药物科学杂志

• 发表时间: 2011
• 期刊: Epub ahead of print
• 作者: Saito J;Hirota T;Kikunaga N;Otsubo K;Ieiri I.
• 通讯作者: Ieiri I.

Ichiro Ieiri Imprinting Analysis of OCTs Genes in Human Placenta

Ichiro Ieiri 人胎盘 OCT 基因印迹分析

• 发表时间: 2010
• 作者: Junpei Saitoh;Takeshi Hirota;Naomi Kikunaga
• 通讯作者: Naomi Kikunaga