Epigenetic regulation of CYP3A4 gene and individual phenotypic status
Epigenetic regulation of CYP3A4 gene and individual phenotypic status
批准号:
21790151
负责人:
HIROTA Takeshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We show that DNA methylation in CYP3A4 enhancer region is critically involved in determining the individual hepatic CYP3A4 mRNA level. Chromosome Conformation Capture assay suggested long-range cis-interaction between the enhancer region and the transcription start site.
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会议论文
Interindividual differences in placental expression of the SLC22A2(OCT2)gene: Relationship to epigenetic variations in the 5'-upstream regulatory region.Journal of Pharmaceutical Sciences
SLC22A2(OCT2)基因胎盘表达的个体差异:与5上游调控区表观遗传变异的关系。药物科学杂志
DOI:
--
发表时间:
2011
期刊:
Epub ahead of print
影响因子:
--
作者:
[Saito J, Hirota T, Kikunaga N, Otsubo K, Ieiri I.]
通讯作者:
Ieiri I.
Ichiro Ieiri Imprinting Analysis of OCTs Genes in Human Placenta
Ichiro Ieiri 人胎盘 OCT 基因印迹分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Junpei Saitoh, Takeshi Hirota, Naomi Kikunaga]
通讯作者:
Naomi Kikunaga
The curriculum development of the training of teachers with the practice power and the teaching materials database for local contribution
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批准号:23530973
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.08万
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财政年份:2011
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负责人:HIROTA Takeshi
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依托单位:
海外基金