Associations of hepatocyte nuclear factors HNF3 and HNF6 to quantitative variation of drug metabolizing enzymes
Associations of hepatocyte nuclear factors HNF3 and HNF6 to quantitative variation of drug metabolizing enzymes
批准号:
21790165
负责人:
OZEKI Takeshi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In the present study, I investigated genetic polymorphisms of the HNF3 and HNF6 genes, and carried out an association study. Tag-SNPs containing the HNF3 and HNF6 genes were chosen by using a HapMap database, and performed an association study concerned with the appearance of the digestive organ toxicity by the doxorubicin. As a result, 2 SNPs located in the 5'-flanking region of the HNF3 gamma gene and a SNP in the 3'-downstream region of the HNF 6 beta gene showed significant associations with the digestive organ toxicity by the doxorubicin.
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会议论文
ネフローゼ症候群患者における糖質コルチコイド感受性とNR3C1遺伝子多型との関連性
肾病综合征患者糖皮质激素敏感性与NR3C1基因多态性的关系
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[大関健志, 莚田泰誠, 鎌谷直之, 中村祐輔]
通讯作者:
中村祐輔
Establishment of personalized administration method of infliximab for Crohn's disease
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批准号:19790139
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.21万
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财政年份:2007
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负责人:OZEKI Takeshi
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依托单位:
Optical Fiber Dispersion Equalization based on Quantum Nonlinear Optical Signal Processing using Optical parametric Amplifiers and Optical Products Summation Operation
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批准号:14350207
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.91万
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财政年份:2002
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负责人:OZEKI Takeshi
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依托单位:
ATM photonic switching systems with Tera-bits/sec throughput
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批准号:06452245
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.48万
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财政年份:1994
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负责人:OZEKI Takeshi
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依托单位:
海外基金