Associations of hepatocyte nuclear factors HNF3 and HNF6 to quantitative variation of drug metabolizing enzymes

肝细胞核因子HNF3和HNF6与药物代谢酶定量变化的关系

• 批准号: 21790165
• 负责人: OZEKI Takeshi
• 金额: $ 2.75万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790165/
• 关键词: 遺伝子; 発現制御; 薬剤反応性; 転写因子

In the present study, I investigated genetic polymorphisms of the HNF3 and HNF6 genes, and carried out an association study. Tag-SNPs containing the HNF3 and HNF6 genes were chosen by using a HapMap database, and performed an association study concerned with the appearance of the digestive organ toxicity by the doxorubicin. As a result, 2 SNPs located in the 5'-flanking region of the HNF3 gamma gene and a SNP in the 3'-downstream region of the HNF 6 beta gene showed significant associations with the digestive organ toxicity by the doxorubicin.

在本研究中，我调查了HNF3和HNF6基因的遗传多态性，并进行了关联研究。利用HapMap数据库筛选出含有HNF3和HNF6基因的Tag-SNPs，并进行了与阿霉素引起的消化器官毒性相关的关联研究。结果显示，位于HNF3γ基因5‘侧翼区的2个SNP和HNF6β基因3’下游的1个SNP与阿霉素引起的消化器官毒性显著相关。

项目成果

ネフローゼ症候群患者における糖質コルチコイド感受性とNR3C1遺伝子多型との関連性

肾病综合征患者糖皮质激素敏感性与NR3C1基因多态性的关系

• 发表时间: 2010
• 作者: 大関健志;莚田泰誠;鎌谷直之;中村祐輔
• 通讯作者: 中村祐輔