Research on the activation mechanism of volume-sensitive ion channels in neurons and glia

神经元和胶质细胞体积敏感离子通道激活机制研究

• 批准号: 21790216
• 负责人: AKITA Tenpei
• 金额: $ 2.5万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790216/
• 关键词: 細胞容積調節; イオンチャネル; アストログリア; ブラジキニン; カルシウムイオン; カルシウムナノドメイン; 活性酸素種; 細胞間情報伝達; Ca^<2+>ナノドメイン; ATP; グルタミン酸

We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.

我们研究了中枢神经系统中对细胞体积、形状和命运最有影响力的调节因子之一——体积敏感的外向整流（VSOR）阴离子通道的激活机制。在本研究期间，我们特别发现了主要神经胶质细胞、星形胶质细胞中 VSOR 通道激活的基本机制，即使对周围组织发生的微小损伤也能以高保真度和确定性做出反应。

项目成果

Bradykinin-induced glutamate release via volume-sensitive outwardly rectifying (VSOR) anion channels in mouse cortical astrocytes.

缓激肽通过小鼠皮质星形胶质细胞中体积敏感的外向整流 (VSOR) 阴离子通道诱导谷氨酸释放。

• 发表时间: 2009
• 作者: 秋田天平;岡田泰伸;秋田天平(発表代表者)
• 通讯作者: 秋田天平(発表代表者)

ホームページ等(論文(2)に関して)

主页等（关于论文（2））

Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes

• DOI: 10.1113/jphysiol.2011.208173
• 发表时间: 2011-08-15
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Akita, Tenpei;Okada, Yasunobu
• 通讯作者: Okada, Yasunobu

Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels

• DOI: 10.1113/jphysiol.2008.165084
• 发表时间: 2009-05-15
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Liu, Hong-Tao;Akita, Tenpei;Okada, Yasunobu
• 通讯作者: Okada, Yasunobu

Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying (VSOR) anion channels via "Ca^<2+> nanodomains" in mouse cortical astrocytes.

通过小鼠皮质星形胶质细胞中的“Ca ^ 2 纳米结构域”调节缓激肽诱导的体积敏感外向整流（VSOR）阴离子通道的激活。

• 发表时间: 2010
• 作者: Liu HT;Akita T et al.;秋田天平(発表代表者)
• 通讯作者: 秋田天平(発表代表者)