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Research on the activation mechanism of volume-sensitive ion channels in neurons and glia

Research on the activation mechanism of volume-sensitive ion channels in neurons and glia
神经元和胶质细胞体积敏感离子通道激活机制研究
批准号:
21790216
负责人:
AKITA Tenpei
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.
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会议论文
Bradykinin-induced glutamate release via volume-sensitive outwardly rectifying (VSOR) anion channels in mouse cortical astrocytes.
缓激肽通过小鼠皮质星形胶质细胞中体积敏感的外向整流 (VSOR) 阴离子通道诱导谷氨酸释放。
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [秋田天平, 岡田泰伸, 秋田天平(発表代表者)]
通讯作者: 秋田天平(発表代表者)
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主页等(关于论文(2))
DOI: --
发表时间:
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作者: []
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DOI: 10.1113/jphysiol.2011.208173
发表时间: 2011-08-15
期刊: JOURNAL OF PHYSIOLOGY-LONDON
影响因子: 5.5
作者: [Akita, Tenpei, Okada, Yasunobu]
通讯作者: Okada, Yasunobu
DOI: 10.1113/jphysiol.2008.165084
发表时间: 2009-05-15
期刊: JOURNAL OF PHYSIOLOGY-LONDON
影响因子: 5.5
作者: [Liu, Hong-Tao, Akita, Tenpei, Okada, Yasunobu]
通讯作者: Okada, Yasunobu
9
    Mechanisms and roles of volume-sensitive anion channel activation mediated by chemical transmitters released in response to cell membrane stretch
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