Research on the activation mechanism of volume-sensitive ion channels in neurons and glia
Research on the activation mechanism of volume-sensitive ion channels in neurons and glia
批准号:
21790216
负责人:
AKITA Tenpei
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
We investigated the activation mechanism of one of the most influential regulators of cell volume, shape and fate, the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system. Within this research period, we have found especially a fundamental mechanism of VSOR channel activation in the major glial cells, astrocytes, which would operate even in response to a minute damage happening in surrounding tissues with high fidelity and certainty.
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Bradykinin-induced glutamate release via volume-sensitive outwardly rectifying (VSOR) anion channels in mouse cortical astrocytes.
缓激肽通过小鼠皮质星形胶质细胞中体积敏感的外向整流 (VSOR) 阴离子通道诱导谷氨酸释放。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[秋田天平, 岡田泰伸, 秋田天平(発表代表者)]
通讯作者:
秋田天平(発表代表者)
ホームページ等(論文(2)に関して)
主页等(关于论文(2))
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DOI:
10.1113/jphysiol.2011.208173
发表时间:
2011-08-15
期刊:
JOURNAL OF PHYSIOLOGY-LONDON
影响因子:
5.5
作者:
[Akita, Tenpei, Okada, Yasunobu]
通讯作者:
Okada, Yasunobu
DOI:
10.1113/jphysiol.2008.165084
发表时间:
2009-05-15
期刊:
JOURNAL OF PHYSIOLOGY-LONDON
影响因子:
5.5
作者:
[Liu, Hong-Tao, Akita, Tenpei, Okada, Yasunobu]
通讯作者:
Okada, Yasunobu
Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying (VSOR) anion channels via "Ca^<2+> nanodomains" in mouse cortical astrocytes.
通过小鼠皮质星形胶质细胞中的“Ca ^ 2 纳米结构域”调节缓激肽诱导的体积敏感外向整流(VSOR)阴离子通道的激活。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Liu HT, Akita T et al., 秋田天平(発表代表者)]
通讯作者:
秋田天平(発表代表者)
共 9 条
Mechanisms and roles of volume-sensitive anion channel activation mediated by chemical transmitters released in response to cell membrane stretch
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批准号:23612008
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:AKITA Tenpei
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依托单位:
海外基金