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The identification of a novel mechanism of osteoclast differentiation that is calcium oscillation-independent osteoclastogenesis

The identification of a novel mechanism of osteoclast differentiation that is calcium oscillation-independent osteoclastogenesis
破骨细胞分化的新机制的鉴定,即钙振荡独立的破骨细胞生成
批准号:
21790220
负责人:
KURODA Yukiko
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010

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中文摘要
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英文摘要
By analysis of osteoclasts derived from IRBIT knockout mice, we found that the number of RANKL-induced Ca^<2+> oscillation positive cells was increased in IRBIT knockout mononuclear osteoclasts and that IRBIT knockout cells enhanced cell-cell fusion step during osteoclastogenesis as compared with wild-type cells. These results indicate that IRBIT negatively regulates IP_3R-mediated Ca^<2+> signaling and cell-cell fusion step during osteoclast differentiation.
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会议论文
IRBITの中枢神経系における分布について
IRBIT在中枢神经系统的分布
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [水谷顕洋, 御子柴克彦, 安東英明, 黒田査孟王, 河合克宏]
通讯作者: 河合克宏
DOI: 10.1074/jbc.m807136200
发表时间: 2009-04-17
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Kiefer, Helene, Mizutani, Akihiro, Mikoshiba, Katsuhiko]
通讯作者: Mikoshiba, Katsuhiko
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [黒田有希子, 久恒智博, 中村健, 松尾光一]
通讯作者: 松尾光一
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [黒田有希子, 久恒智博, 中村健, 松尾光一, 黒田有希子]
通讯作者: 黒田有希子
Analysis of hypermineralizing osteoblasts, a new osteoblast subtype, that produce high BMD bone
  • 批准号:
    19K07256
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2019
  • 负责人:
    KURODA Yukiko
  • 依托单位:
The investigation and identification of key molecules in the calciumoscillation-independent osteoclastogenesis
  • 批准号:
    23790265
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.83万
  • 财政年份:
    2011
  • 负责人:
    KURODA Yukiko
  • 依托单位:
Involvement of a novel mitochondria protein in the Parkinson's disease : The establishment of a new therapeutic target
  • 批准号:
    20790616
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2008
  • 负责人:
    KURODA Yukiko
  • 依托单位:
The clarification of the regulatory mechanism of calcium dynamics during osteoclastogenesis
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