The identification of a novel mechanism of osteoclast differentiation that is calcium oscillation-independent osteoclastogenesis
The identification of a novel mechanism of osteoclast differentiation that is calcium oscillation-independent osteoclastogenesis
批准号:
21790220
负责人:
KURODA Yukiko
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
By analysis of osteoclasts derived from IRBIT knockout mice, we found that the number of RANKL-induced Ca^<2+> oscillation positive cells was increased in IRBIT knockout mononuclear osteoclasts and that IRBIT knockout cells enhanced cell-cell fusion step during osteoclastogenesis as compared with wild-type cells. These results indicate that IRBIT negatively regulates IP_3R-mediated Ca^<2+> signaling and cell-cell fusion step during osteoclast differentiation.
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IRBITの中枢神経系における分布について
IRBIT在中枢神经系统的分布
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[水谷顕洋, 御子柴克彦, 安東英明, 黒田査孟王, 河合克宏]
通讯作者:
河合克宏
DOI:
10.1074/jbc.m807136200
发表时间:
2009-04-17
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Kiefer, Helene, Mizutani, Akihiro, Mikoshiba, Katsuhiko]
通讯作者:
Mikoshiba, Katsuhiko
御子柴克彦生体内における破骨細胞分化はカルシウムオシレーション依存的・および非依存的メカニズムによって制御されている
Katsuhiko Mikoshiba 体内破骨细胞分化受钙振荡依赖性和非依赖性机制控制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[黒田有希子, 久恒智博, 中村健, 松尾光一]
通讯作者:
松尾光一
生体内における破骨細胞分化なカルシウムオシレーション依存的・および非依存的メカニズムによって制御されている
体内破骨细胞分化受到钙振荡依赖性和非依赖性机制的调节。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[黒田有希子, 久恒智博, 中村健, 松尾光一, 黒田有希子]
通讯作者:
黒田有希子
Analysis of hypermineralizing osteoblasts, a new osteoblast subtype, that produce high BMD bone
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批准号:19K07256
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.75万
-
财政年份:2019
-
负责人:KURODA Yukiko
-
依托单位:
The investigation and identification of key molecules in the calciumoscillation-independent osteoclastogenesis
-
批准号:23790265
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2011
-
负责人:KURODA Yukiko
-
依托单位:
Involvement of a novel mitochondria protein in the Parkinson's disease : The establishment of a new therapeutic target
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批准号:20790616
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:KURODA Yukiko
-
依托单位:
The clarification of the regulatory mechanism of calcium dynamics during osteoclastogenesis
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批准号:19890273
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$1.97万
-
财政年份:2007
-
负责人:KURODA Yukiko
-
依托单位:
海外基金