The effect of stress on ovarian function via activation of hypothalamic-pituitary hormones and sympathetic nerves.

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The present experiments examined the effects of stress stimulation on the estradiol concentration in peripheral blood plasma. Using anesthetized rats, application of noxious stimulation to the hind paw for five minutes, and of electrical stimulation, with an supramaximal intensity, directly to the ovarian sympathetic nerve for five minutes, both resulted in no change in the estradiol concentration in peripheral blood plasma. On the other hand, by the same stimulations, the secretion rate of ovarian estradiol was reduced by approximately 30% and by approximately 50%, respectively. These results showed that reduction of the secretion rate of ovarian estradiol by short-term stress stimulation is not reflected in the peripheral blood.