Identification of Molecular Targets for Valproic Acid in Membrane Transport System Using Fission Yeast Model Organism

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Valproic acid (VPA) is widely used as an anticonvulsant. More recently, it has been reported that VPA reinforces action of the anticancer drug, improves the reprogramming efficiency in the induction of pluripotent stem cells, and dramatically enhances the restoration of hind limb function after transplantation of neural stem cells. The exact mechanisms of action of VPA in these conditions remain unclear, although it has been shown to alter a wide variety of signaling pathways. To gain further insights into the molecular mechanisms of drug action, we have developed a genetic screen for mutants that show hypersensitivity to VPA in fission yeast. We found that VPA is involved in intracellular membrane trafficking.