Search of regulatory factors in neural glutathione concentration

谷氨酸是保护细胞的必需还原剂，并且在神经退行性疾病如帕金森病中被还原。神经元主要依赖于细胞外半胱氨酸合成谷胱甘肽和半胱氨酸转运蛋白称为兴奋性氨基酸载体1（EAAC 1）。我以前显示GTRAP 3 -18（EAAC 1的谷氨酸转运相关蛋白）与EAAC 1相互作用，从而调节神经元谷胱甘肽水平。在此，我指出了GTRAP 3 -18的磷酸化，这是寻找神经谷胱甘肽浓度调节因子的关键信息。

Glutathione is an essential reductant which protects cells and is reduced in neurodegenerative disorders such as a Parkinson's disease. Neurons rely mainly on extracellular cysteine for glutathione synthesis and a cysteine transporter termed excitatory amino acid carrier-1 (EAAC1). I previously showed GTRAP3-18 (glutamate transport associated protein for EAAC1) to interact with EAAC1 and thereby regulate neuronal glutathione levels. In this time, I indicated the phosphorylation of GTRAP3-18, which is a key of information to search regulatory factors in neural glutathione concentration.