CommonMechanismforCancerProgressionandStratificationofEpithelia

癌症进展和上皮分层的共同机制

• 批准号: 21790267
• 负责人: MATSUI Takeshi
• 金额: $ 2.75万
• 依托单位: Kyoto University (2011-2012)Tokyo Medical and Dental University (2009-2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790267/
• 关键词: 癌; 細胞・組織; 発生・分化; プロテアーゼ; 皮膚; 表皮; 上皮; 欠損マウス; SASPase; Dermokine; 上皮細胞; dermokine; 早期癌; 分泌蛋白質; ノックアウトマウス; アイソフォーム; 重層扁平上皮組織

Skin-specific secreted peptide, dermokine was expressed in colorectal and pancreatic cancer at the early-stageof carcinogenesis. Serum dermokine was potential biomarker in these cancers. In addition, activity of skin-specific protease, SASPase plays a key role in stratum corneum hydration through profilaggrin processing. SASPase was also expressed at the early-stage of carcinogenesis. These results suggested the potential link between cancer progression and stratification of epithelia.

皮肤特异性分泌肽dermokine在结直肠癌和胰腺癌癌变早期表达。血清真皮因子是这些癌症的潜在生物标志物。此外，皮肤特异性蛋白酶SASPase的活性在角质层水化过程中发挥关键作用。SASPase在癌变早期也有表达。这些结果提示癌症进展和上皮分层之间的潜在联系。

项目成果

Mammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and Evolution. RSC-iCeMS Joint IaMammalian Skin-specific Retroviral-like Aspartic Protease, SASPase is a Key Modulator of Skin Moisturization and

哺乳动物皮肤特异性逆转录病毒样天冬氨酸蛋白酶，SASPase 是皮肤保湿和进化的关键调节剂。

• 发表时间: 2012
• 作者: 藤田佳子;垣野明美;乙井一典;山口三郎;佐藤優子;小倉紗世子;岩元真;沢村達也;Hideo Shindou.;Matsui T
• 通讯作者: Matsui T

Evolutionally integrated retroviral-like aspartic protease, SASPase regulates stratum corneum hydration through profilaggrin-to-filaggrin processing

进化整合的逆转录病毒样天冬氨酸蛋白酶，SASPase 通过聚丝蛋白原到聚丝蛋白加工调节角质层水合作用

• 发表时间: 2011
• 作者: 松井 毅;松井 毅;松井 毅;Matsui T
• 通讯作者: Matsui T

Analysis and clinical application of dermokines, stratified epithelia-specific secreted proteins

皮肤因子、复层上皮特异性分泌蛋白的分析及临床应用

• 发表时间: 2009
• 作者: Matsui T;Miyamoto K;Kubo A;Kawasaki H;Ebihara T;Hata K;Tanahashi S;Ichinose S;Imoto I;Inazawa J;Kudoh J;Amagai M;Matsui T;Matsui T;Matsui T
• 通讯作者: Matsui T

表皮の顆粒層特異的に発現するプロテアーゼSASPaseによる、角質層水分量の制御機構

SASPase（一种在表皮颗粒层特异性表达的蛋白酶）对角质层含水量的控制机制

• 发表时间: 2011
• 作者: 松井毅;宮本憲;久保亮治;川崎洋;海老原全;畑和也;市野瀬志津子;井本逸勢;稲澤譲治;工藤純;天谷雅行;Matsui T
• 通讯作者: Matsui T

Treatment of Dry Skin Syndrome -The Art and Science of Moisturizers-

干燥皮肤综合症的治疗 - 保湿霜的艺术与科学 -

• 发表时间: 2012
• 作者: Matsui T;Miyamoto K;Kubo A;Kawasaki H;Ebihara T;Hata K;Tanahashi S;Ichinose S;Imoto I;Inazawa J;Kudoh J;Amagai M;Matsui T;Matsui T;Matsui T;松井毅;Matsui T;Matsui T;T Matsui
• 通讯作者: T Matsui