Studies on the roles of Periplakin in liver

Periplakin对肝脏作用的研究

• 批准号: 21790272
• 负责人: ITO Shinji
• 金额: $ 2.75万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790272/
• 关键词: 肝臓; 遺伝子発現; 恒常性維持; Periplakin; 胆汁鬱滞; FXR; 炎症; 胆汁酸; 遺伝子発現制御

Periplakin is one of the plakin family of cytokinker proteins whose physiological roles in vivo is not fully elucidated. We have revealed that periplakin massively accumulates in hepatocytes following cholestatic injury. In addition, periplakin-null mice exhibited difference in the expression of genes related to hepatic homeostasis. Therefore, periplakin is likely involved in keeping hepatic homeostasis under cholestatic situations in liver.

Periplakin是细胞分裂蛋白plakin家族中的一员，其在体内的生理作用尚未完全阐明。我们发现，在胆汁淤积损伤后，periplakin在肝细胞中大量积累。此外，无periplakin的小鼠在肝脏稳态相关基因的表达上表现出差异。因此，在肝脏胆汁淤积的情况下，periplakin可能参与维持肝脏内稳态。

项目成果

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

• DOI: 10.1073/pnas.0913986107
• 发表时间: 2010-01-26
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Tomiyama, Ken-ichi;Maeda, Ryota;Nabeshima, Yo-ichi
• 通讯作者: Nabeshima, Yo-ichi