Rhomboid regulates innate immunity via TNFα signaling

先天免疫反应对病原体防御至关重要，但过度时会导致感染性休克。感染性休克的一个关键介质是肿瘤坏死因子α，它被蛋白酶TACE从质膜上切割后进入细胞间隙。在此，我们报道了RHBDF2家族成员在体内外与肿瘤血管内皮细胞生长因子相互作用并调节肿瘤坏死因子α的脱落。我们的研究确定RHBDF2是一种新的天然免疫调节因子，可能是调节脓毒症和病原体防御的重要靶点。

Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is TNFα, which is shed into intercellular spaces after cleavage from the plasma membrane by the protease TACE. Here we report that the rhomboid family member RHBDF2 interacts with TACE and regulates TNFαshedding in vitro and in vivo. Our study has identified RHBDF2 as a novel regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense.