Rhomboid regulates innate immunity via TNFα signaling

菱形通过 TNFα 信号传导调节先天免疫

• 批准号: 21790281
• 负责人: HAMADA Koichi
• 金额: $ 2.75万
• 依托单位: Kumamoto University (2010)Kyushu University (2009)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790281/
• 关键词: 細胞増殖; 細胞死; セリンプロテアーゼ; 炎症; 胎生致死; 遺伝子改変マウス; プロテアーゼ

Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is TNFα, which is shed into intercellular spaces after cleavage from the plasma membrane by the protease TACE. Here we report that the rhomboid family member RHBDF2 interacts with TACE and regulates TNFαshedding in vitro and in vivo. Our study has identified RHBDF2 as a novel regulator of innate immunity that may be an important target for modulating sepsis and pathogen defense.

先天免疫反应对病原体防御至关重要，但当过度时可导致感染性休克。脓毒性休克的一个关键介质是TNFα，它通过蛋白酶TACE从质膜裂解后进入细胞间隙。在这里，我们报道了菱形家族成员RHBDF2在体外和体内与TACE相互作用并调节tnf α脱落。我们的研究已经发现RHBDF2是一种新的先天免疫调节剂，可能是调节败血症和病原体防御的重要靶点。