Targeting endothelial lipase as a novel therapeutic strategy for the treatment of atherosclerosis

为了建立一种提高血浆HDL-胆固醇水平的新策略，我们使用兔模型分析了内皮脂酶（EL）的功能，EL是一种新发现的HDL磷脂酶。我们发现，EL的表达增加，在兔与低HDL-胆固醇水平。使用EL特异性反义抑制EL表达导致血浆HDL-胆固醇水平升高。这些结果表明，治疗性抑制EL活性可能成为提高血浆HDL水平的新手段。

To establish a novel strategy for raising plasma HDL-cholesterol levels, we analyzed the functions of endothelial lipase (EL), a newly-identified HDL phospholipase, using rabbit models. We found that EL expression was increased in rabbits with low HDL-cholesterol levels. Inhibition of EL expression using EL specific antisense led to increased plasma HDL-cholesterol levels. These results indicate the therapeutic inhibition of EL activity may become a new mean to elevate plasma HDL levels.