Analysis of apolipoprotein CIII function with transgenic rabbit
Analysis of apolipoprotein CIII function with transgenic rabbit
转基因兔载脂蛋白CIII功能分析
批准号：
21790322
负责人：
NISHIJIMA Kazutoshi
金额：
$1.66万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009 至 2011
中文摘要
翻译
我们试图建立一个转基因家兔作为工具来分析载脂蛋白（apo） CIII在脂质代谢中的功能。用人apoCIII表达DNA构建体微注射2727个卵细胞。将2276个胚胎移植到87只受体家兔中，共产生24只后代。PCR分析结果显示，后代中未发现人类apoCIII基因的整合。
英文摘要
We attempted to create a transgenic rabbit as a tool to analyze the function of apolipoprotein(apo) CIII on lipid metabolism. 2727 ova were microinjected with human apoCIII expression DNA construct. 2276 embryos were transferred into 87 recipient rabbits, and 24 offspring were born. As a result of PCR analysis, no integration of human apoCIII gene was recognized in the offspring.
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会议论文
Effects of lipoprotein lipase and apolipoprotein AII on exercise regimen for obesity.
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批准号：24790320
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.75万
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财政年份：2012
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负责人：NISHIJIMA Kazutoshi
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依托单位：
海外基金
