Epigenetic therapy for gastric cancer by targeting microRNAs

在本研究中，使用DNA甲基化抑制剂和组蛋白脱乙酰酶抑制剂的表观遗传疗法激活了人胃癌细胞中的肿瘤抑制基因microRNA miR-512-5p。表观遗传疗法激活miR-512-5p可抑制MCL-1，导致胃癌细胞凋亡。此外，我们的研究表明，microRNAs在功能性胃肠道疾病包括功能性消化不良的发病机制中发挥重要作用。本研究结果可能为胃肠道恶性肿瘤和功能性胃肠道疾病的治疗提供新的途径。

In the present study, epigenetic therapy using DNA methylation inhibitors and histone deacetylase inhibitors activates the tumor suppressor microRNA miR-512-5p in human gastric cancer cells. Activation of miR-512-5p by epigenetic therapy induces suppression of MCL-1, resulting in apoptosis of gastric cancer cells.In addition, our study suggests that microRNAs play important roles in the pathogenesis of functional gastrointestinal disorders including functional dyspepsia.The results in the present study may provide a novel therapeutic approach for gastrointestinal malignancies as well as functional gastrointestinal disorders.