Epigenetic therapy for gastric cancer by targeting microRNAs

在本研究中，使用DNA甲基化抑制剂和组蛋白去乙酰化酶抑制剂的表观遗传疗法激活了人胃癌细胞中的肿瘤抑制microRNA miR-512- 5 p。通过表观遗传学方法激活miR-512- 5 p，抑制MCL-1表达，导致胃癌细胞凋亡，提示microRNA在功能性消化不良等功能性胃肠疾病的发病机制中起重要作用，为胃肠道恶性肿瘤及功能性胃肠疾病的治疗提供了新的思路。

In the present study, epigenetic therapy using DNA methylation inhibitors and histone deacetylase inhibitors activates the tumor suppressor microRNA miR-512-5p in human gastric cancer cells. Activation of miR-512-5p by epigenetic therapy induces suppression of MCL-1, resulting in apoptosis of gastric cancer cells.In addition, our study suggests that microRNAs play important roles in the pathogenesis of functional gastrointestinal disorders including functional dyspepsia.The results in the present study may provide a novel therapeutic approach for gastrointestinal malignancies as well as functional gastrointestinal disorders.