Molecular pathology of the mechanism of the invasion and metastasis of cholangiocarcinoma-From the aspects of epithelial-mesenchymal transition

上皮-间质转化（Epithelial-mesenchymal transition， EMT）是肿瘤侵袭转移的重要机制。本研究旨在阐明EMT在胆管癌进展中的作用。利用胆管癌细胞系和手术切除的胆管癌标本进行的研究表明，转化生长因子-β1/Snail激活诱导的EMT与胆管癌的侵袭性生长密切相关，导致预后不良。

Epithelial-mesenchymal transition (EMT) is an important mechanism behind the initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of EMT in the progression of cholangiocarcinoma. Studies using cholangiocarcinoma cell lines and surgically resected specimens of cholangiocarcinoma demonstrated that EMT induced by transforming growth factor-β1/Snail activation was closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis.