Molecular pathology of the mechanism of the invasion and metastasis of cholangiocarcinoma-From the aspects of epithelial-mesenchymal transition

胆管癌侵袭转移机制的分子病理学——从上皮间质转化角度

• 批准号: 21790346
• 负责人: SATO Yasunori
• 金额: $ 2.16万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790346/
• 关键词: 人体病理学; 肝臓; 胆管癌; 上皮・間葉変換

Epithelial-mesenchymal transition (EMT) is an important mechanism behind the initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of EMT in the progression of cholangiocarcinoma. Studies using cholangiocarcinoma cell lines and surgically resected specimens of cholangiocarcinoma demonstrated that EMT induced by transforming growth factor-β1/Snail activation was closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis.

上皮间质转化（EMT）是癌症侵袭和转移启动的重要机制。本研究旨在阐明 EMT 在胆管癌进展中的作用。使用胆管癌细胞系和手术切除的胆管癌标本的研究表明，转化生长因子-β1/Snail激活诱导的EMT与胆管癌的侵袭性生长密切相关，导致预后不良。

项目成果

Epitheli al-mesenchymal transition induced by transforming growth factor-・1/Snai l activationaggravates invasive grow th of cholangiocarcinoma.

转化生长因子-·1/Snail激活诱导的上皮间质转化加剧了胆管癌的侵袭性生长。

• 发表时间: 2010
• 期刊: Am J Pathol 177
• 作者: Sato Y;Harada K;Itatsu K;Ikeda H;Kakuda Y;Shimomura S;Ren XS;Yone da N;Sasaki M;Nakanuma Y.
• 通讯作者: Nakanuma Y.

Epithelial-mesenchymal transition induced by transforming growth factor-・1 aggravates invasive growth of cholangiocarcinoma.

转化生长因子-·1诱导的上皮-间质转化加剧了胆管癌的侵袭性生长。

• 发表时间: 2009
• 作者: Sato Y;Yoneda N;Ren XS;Sasaki M;Harada K;Nakanuma Y.
• 通讯作者: Nakanuma Y.

胆管癌の浸潤・転移機構における上皮-間葉変換(EMT)の関与

上皮间质转化（EMT）参与胆管癌侵袭转移机制

• 发表时间: 2009
• 作者: 佐藤保則;下村修治;角田優子;池田博子;佐々木素子;原田憲一;中沼安二
• 通讯作者: 中沼安二

Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor-β1/Snail Activation Aggravates Invasive Growth of Cholangiocarcinoma

• DOI: 10.2353/ajpath.2010.090747
• 发表时间: 2010-07-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Sato, Yasunori;Harada, Kenichi;Nakanuma, Yasuni
• 通讯作者: Nakanuma, Yasuni

胆管硬化とEMT

胆道硬化和 EMT

• 发表时间: 2011
• 期刊: 肝胆膵 62
• 作者: 佐藤保則;原田憲一;中沼安二
• 通讯作者: 中沼安二