Study Design and Statistical Analysis in a Genome-Wide Pharmacogenomics Study

本研究的目的是从统计学的角度审视全基因组药物基因组学研究的研究设计和分析方法存在的问题，并提出新的建议，以促进个性化研究的发展。在这项研究中，关于全基因组药物基因组学研究的三个具体问题如下：i)药代动力学与SNP之间的关联的统计分析，ii)临床结果与SNP之间的关联的统计分析，iii)PK和SNP-PD模型的统计分析。这些研究结果发表在学术期刊和会议上。

The purpose of this research is to examine problems of study design and analyzing methods for genome-wide pharmacogenomics studies from statistical viewpoints, and then to present new proposals in order to contribute to the development of personalized. In this study, three specific issues were addressed regarding the genome-wide pharmacogenomics studies as follows ; i) Statistical analysis for the association between pharmacokinetics and SNP, ii) Statistical analysis for the association between clinical outcome and SNP, iii) Statistical analysis for PK and SNP-PD modeling. These findings of research were reported in academic journals and meetings.