Study Design and Statistical Analysis in a Genome-Wide Pharmacogenomics Study

全基因组药物基因组学研究中的研究设计和统计分析

• 批准号: 21890035
• 负责人: SATO Yasunori
• 金额: $ 1.7万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890035/
• 关键词: ゲノム; 薬剤反応性; 統計科学; 遺伝疫学; ゲノム網羅的アプローチ; ファーマコゲノミクス; 一塩基多型(SNP); 生物統計手法; 母集団薬物動態解析; 一塩基多型; 薬物動態解析; 統計学的アプローチ; 生存時間解析

The purpose of this research is to examine problems of study design and analyzing methods for genome-wide pharmacogenomics studies from statistical viewpoints, and then to present new proposals in order to contribute to the development of personalized. In this study, three specific issues were addressed regarding the genome-wide pharmacogenomics studies as follows ; i) Statistical analysis for the association between pharmacokinetics and SNP, ii) Statistical analysis for the association between clinical outcome and SNP, iii) Statistical analysis for PK and SNP-PD modeling. These findings of research were reported in academic journals and meetings.

本研究旨在从统计学角度探讨全基因组药物基因组学研究设计和分析方法中存在的问题，并提出新的建议，以促进个性化药物基因组学研究的发展。本研究针对全基因组药物基因组学研究的三个具体问题进行了探讨：i)药代动力学与SNP相关性的统计分析ii)临床结局与SNP相关性的统计分析iii) PK和SNP- pd建模的统计分析。这些研究结果发表在学术期刊和会议上。

项目成果

Studentized modified maximum contrast method for unequal sample sizes in pharmacogenomics Studies.

针对药物基因组学研究中不等样本量的学生化修改最大对比度方法。

• 发表时间: 2010
• 作者: Nagashima K;Sato Y. Hamada C.
• 通讯作者: Sato Y. Hamada C.

Studentized modified maximum contrast method for unequal sample sizes in pharmacogenomics STUDIES

药物基因组学研究中样本量不等的学生化改良最大对比法

• 发表时间: 2010
• 作者: Nagashima K;Sato Y;Hamada C.
• 通讯作者: Hamada C.

Genome-wide association scan detected candidate polymorphisms associated with overall survival (OS) in advanced non-small cell lung cancer (NSCLC) treated with carboplatin (CBDCA) and paclitaxel (PTX).

全基因组关联扫描检测到与卡铂 (CBDCA) 和紫杉​​醇 (PTX) 治疗的晚期非小细胞肺癌 (NSCLC) 总体生存 (OS) 相关的候选多态性。

• 发表时间: 2009
• 作者: Sato Y;Yamamoto N;Tamura T;Kunitoh H;Ohe Y;Katori N;Sawada J;Sakamoto H;Saijo N;Yoshida T.
• 通讯作者: Yoshida T.

Genome-wide association study detected candidate polvmorphisms associated with overall survival (OS) in advanced non-small cell lung cancer treated with carboplatin and paclitaxel.

全基因组关联研究检测到与卡铂和紫杉醇治疗的晚期非小细胞肺癌的总生存期 (OS) 相关的候选多态性。

• 发表时间: 2011
• 期刊: J Thorac Oncol. 6
• 作者: Sato Y;Yamamoto N;Kunitoh H;Ohe Y;Minami H;Laird NM;Katori N;Saito Y;Ohnami S;Sakamoto H;Sawada J;Saijo N;Yoshida T;Tamura T.
• 通讯作者: Tamura T.

Genome-wide association scan detected candidate polymorphisms associated with overall survival in stage IV pancreatic adenocarcinoma patients receiving gemcitabine monotherapy.

全基因组关联扫描检测到与接受吉西他滨单药治疗的 IV 期胰腺腺癌患者的总生存率相关的候选多态性。

• 发表时间: 2009
• 作者: Uenol H;Okusakal T;Furuse J;Ishii H;Saijo N;Saito Y;Sawada J;Sakamoto H;Yoshida T;Sato Y.
• 通讯作者: Sato Y.