Comprehensive analysis base on the interaction between follicular lymphoma cells and follicular dendritic cells

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To elucidate mechanism of lymphomagenesis of follicular lymphoma, we examined comprehensive protein detection analysis using laser microdissection and shotgun proteomics. We detected approximately two thousand kinds of proteins, focused on GRHPR and PACAP, which detected frequently in follicular lymphoma, and non-neoplastic follicle respectively. These genes were over-expressed in transcriptional level and each protein expressions are affirmed in human histology sample. This study suggested these genes are the candidate marker in follicular lymphomagenesis, and further molecular biological and functional analyses are desirable.