Pentraxin 3 in atherosclerotic plaque reduces platelet thrombus formation under flow.

动脉粥样硬化斑块破裂和随后的血栓形成是动脉粥样硬化血栓形成的主要原因，特别是在急性心肌梗死中。炎症生物标志物在动脉粥样硬化血栓形成中起着重要的作用。在这项研究中，我们研究了PTX 3，一种新的炎症生物标志物：在心血管事件中的作用。PTX 3定位于冠状动脉斑块中，在不稳定型心绞痛患者中表达明显增加。PTX 3抑制血小板聚集，并显著减少流动条件下血小板血栓形成。因此，在斑块破裂后，PTX 3可能通过血小板拮抗剂影响血栓形成。

Atherosclerotic plaque disruption with subsequent thrombus formation is a major cause of atherothrombosis, particularly in acute myocardinal infarction. Inflammatory biomarkers play an important rule, in atherothrombosis. In this study, we investigate the role of PTX3, a novel imflammatory biomarker : in cardiovascular event. PTX3 was localized in coronary plaque, and the expression was significantly increased in patients with unstable angina. PTX3 inhibited platelet aggregation, and significantly reduced platelet thrombus formation under flow condition. Thus, PTX3 may affect thrombus formation via a platelet antagonist after plaque disruption.