使用计算机对血栓的形成机制建模是近年来血栓研究的热点。研究的难点之一是计算模型的精确度和逼真度。血栓的几何形态作为影响其形成的一个重要因素直接决定模型的准确性。但是，已有的模型中往往忽略了血栓形态的重要性。本项目通过在计算模型中加入基于水平集的形状建模算法，提高模拟中血栓几何形态的准确度。具体的研究内容和目标如下：1、在混合模型中引入水平集概念，将血栓表面由离散的颗粒表面转换为连续的自由界面，提高血栓几何形态描述的精确度；2、针对计算模型的特点改进水平集方法，降低界面追踪中的计算复杂度，从而提高计算模型的效率；3、通过模拟实验研究动脉中血栓的几何形态与血栓形成间的关系，加深对血栓形成机制的理解。

The computer modeling of the mechanism of thrombosis is a popular research field in thrombosis research. One of the research challenges is the accuracy and fidelity of the computational model. The thrombus morphology which is an important influencing factor of thrombosis determines the model accuracy directly. However, the importance of the thrombus morphology is always ignored in the existing models. The project is mainly focused on increasing the accuracy of thrombus morphology through adding Level Set based shape modeling to the model. The objectives and contents of this project are as follows: 1. Introducing Level Set into the hybrid model to transform the surface of thrombus from discrete particles form to continuous free surface, which increases the accuracy of description of thrombus geometry morphology; 2. Improving Level Set Method according to the features of the model to reduce the computation complexity in surface tracking and raise the efficiency of the computational model. 3. To deepen the understanding of the mechanism of thrombosis, studying the relationship between thrombus morphology and thrombogenesis in artery through simulations.